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Type 2 Diabetes, Skin Autofluorescence, and Brain Atrophy


Moran, C and Munch, G and Forbes, JM and Beare, R and Blizzard, L and Venn, AJ and Phan, TG and Chen, J and Srikanth, V, Type 2 Diabetes, Skin Autofluorescence, and Brain Atrophy, Diabetes, 64, (1) pp. 279-283. ISSN 1939-327X (2015) [Refereed Article]


Copyright Statement

Copyright 2014 American Diabetes Association "This is an author-created, uncopyedited electronic version of an article accepted for publication in Diabetes. The American Diabetes Association (ADA), publisher of Diabetes, is not responsible for any errors or omissions in this version of the manuscript or any version derived from it by third parties. The definitive publisher-authenticated version will be available in a future issue of Diabetes in print and online at"

DOI: doi:10.2337/db14-0506


Type 2 Diabetes Mellitus (T2DM) is associated with brain atrophy, but the mechanisms underlying this link are unknown. Advanced glycation end products (AGEs) accumulate in T2DM resulting in inflammation, oxidative stress, and protein cross-linking, which are known contributors to neurodegeneration. We aimed to study whether tissue AGE accumulation is associated with T2DM-related brain atrophy. We performed brain magnetic resonance imaging (MRI), cognitive tests and non-invasive skin autofluorescence (SAF, a measure of tissue AGE levels) on people aged >55 years with and without T2DM. Multivariable linear regression was used to study the relationships between T2DM, SAF and gray matter volume. There were 486 people included in the study. T2DM was associated with greater SAF. Greater SAF, T2DM and cognitive impairment were each associated with lower gray matter volume independently of age, sex and total intracranial volume. SAF partially mediated the association between T2DM and gray matter volume. Longitudinal studies may help confirm whether tissue AGE accumulation is associated with brain atrophy in T2DM.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Neurology and neuromuscular diseases
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Blizzard, L (Professor Leigh Blizzard)
UTAS Author:Venn, AJ (Professor Alison Venn)
UTAS Author:Srikanth, V (Dr Velandai Srikanth)
ID Code:94534
Year Published:2015 (online first 2014)
Web of Science® Times Cited:46
Deposited By:Menzies Institute for Medical Research
Deposited On:2014-09-11
Last Modified:2017-11-20
Downloads:613 View Download Statistics

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