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Expert consensus for Multimodality Imaging Evaluation of adult patients during and after cancer therapy: a report from the American Society of Echocardiography and the European Association of Cardiovascular Imaging
journal contribution
posted on 2023-05-18, 03:08 authored by Plana, JC, Galderisi, M, Barac, A, Ewer, MS, Ky, B, Scherrer-Crosbie, M, Ganame, J, Sebag, IA, Agler, DA, Badano, LP, Banchs, J, Cardinale, D, Carver, J, Cerqueira, M, DeCara, JM, Edvardsen, T, Flamm, SD, Force, T, Griffin, BP, Jerusalem, G, Liu, JE, Magalhaes, A, Thomas MarwickThomas Marwick, Sanchez, LY, Sicari, R, Villarraga, HR, Lancellotti, PCardiac dysfunction resulting from exposure to cancer therapeutics was first recognized in the 1960s, with the widespread introduction of anthracyclines into the oncologic therapeutic armamentarium. Heart failure (HF) associated with anthracyclines was then recognized as an important side effect. As a result, physicians learned to limit their doses to avoid cardiac dysfunction. Several strategies have been used over the past decades to detect it. Two of them evolved over time to be very useful: endomyocardial biopsies and monitoring of left ven- tricular (LV) ejection fraction (LVEF) by cardiac imaging. Examination of endomyocardial biopsies proved to be the most sensitive and spe- cific parameter for the identification of anthracycline-induced LV dysfunction and became the gold standard in the 1970s. However, the interest in endomyocardial biopsy has diminished over time because of the reduction in the cumulative dosages used to treat ma- lignancies, the invasive nature of the procedure, and the remarkable progress made in noninvasive cardiac imaging. The noninvasive evaluation of LVEF has gained importance, and notwithstanding the limitations of the techniques used for its calculation, has emerged as the most widely used strategy for monitoring the changes in cardiac function, both during and after the administration of potentially car- diotoxic cancer treatment.
History
Publication title
Journal of the American Society of EchocardiographyVolume
27Issue
9Pagination
911-939ISSN
0894-7317Department/School
Menzies Institute for Medical ResearchPublisher
MosbyPlace of publication
Inc, 11830 Westline Industrial Dr, St Louis, USA, Mo, 63146-3318Rights statement
Copyright 2014 by the American Society of EchocardiographyRepository Status
- Restricted