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Genetic and epigenetic variation in vulvar cancer: Current research and future clinical practice
Citation
McWhirter, RE and Marthick, JR and Boyle, JA and Dickinson, JL, Genetic and epigenetic variation in vulvar cancer: Current research and future clinical practice, The Australian and New Zealand Journal of Obstetrics and Gynaecology, 54, (5) pp. 406-411. ISSN 1479-828X (2014) [Refereed Article]
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Copyright Statement
Copyright 2014 The Royal Australian and New Zealand College of Obstetricians and Gynaecologists
Abstract
Vulvar cancer is a relatively rare gynaecological malignancy, the treatment of which is associated with significant patient morbidity. With reports that the incidence of vulvar cancer is increasing, there is a rising need for improved preventive, diagnostic and therapeutic tools. Recent advances within genetics and epigenetics present possible approaches for addressing this need, by contributing to the clarification of the aetiology of this disease, identifying screening and drug targets and introducing the potential for personalised treatments. This paper reviews the genetic and epigenetic research undertaken to date within vulvar cancer, evaluates its potential for clinical application and identifies directions for future research.
© 2014 The Royal Australian and New Zealand College of Obstetricians and Gynaecologists.
Item Details
Item Type: | Refereed Article |
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Keywords: | epigenetics, genetics, human papillomavirus, vulvar cancer, vulvar intraepithelial neoplasia |
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Oncology and carcinogenesis |
Research Field: | Cancer genetics |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | McWhirter, RE (Dr Rebekah McWhirter) |
UTAS Author: | Marthick, JR (Mr James Marthick) |
UTAS Author: | Dickinson, JL (Professor Joanne Dickinson) |
ID Code: | 94397 |
Year Published: | 2014 |
Web of Science® Times Cited: | 4 |
Deposited By: | Menzies Institute for Medical Research |
Deposited On: | 2014-09-09 |
Last Modified: | 2018-12-06 |
Downloads: | 5 View Download Statistics |
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