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Assessment of nonischemic myocardial fibrosis

Citation

Jellis, C and Martin, J and Narula, J and Marwick, TH, Assessment of nonischemic myocardial fibrosis, Journal of the American College of Cardiology, 56, (2) pp. 89-97. ISSN 0735-1097 (2010) [Refereed Article]

Copyright Statement

Copyright 2010 American College of Cardiology Foundation

DOI: doi:10.1016/j.jacc.2010.02.047

Abstract

Myocardial fibrosis is recognized as the pathologic entity of extracellular matrix remodeling. Diffuse, reactive fibrosis is being increasingly recognized in a variety of conditions despite the absence of ischemia. Regardless of the etiology, fibrosis leads to increased myocardial stiffness thereby promoting cardiac dysfunction. This may present clinically with symptoms of cardiac failure although often this is a subclinical disease. Various imaging modalities and collagen biomarkers have been used as surrogate markers to assess the presence, extent, and turnover of myocardial fibrosis. Techniques using echocardiography, cardiac magnetic resonance, and nuclear imaging have been developed to detect early features of systolic and diastolic left ventricular dysfunction and impaired contractile reserve. Further identification of diffuse reactive fibrosis may be possible with evolving cardiac magnetic resonance and molecular techniques. The goal of these approaches is to enable targeted therapy to be instituted earlier, leading to prevention of disease progression and fibrosis accumulation long term.

Item Details

Item Type:Refereed Article
Keywords:fibrosis; myocardial; heart failure
Research Division:Medical and Health Sciences
Research Group:Cardiorespiratory Medicine and Haematology
Research Field:Cardiology (incl. Cardiovascular Diseases)
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Cardiovascular System and Diseases
Author:Marwick, TH (Professor Tom Marwick)
ID Code:94046
Year Published:2010
Web of Science® Times Cited:96
Deposited By:Menzies Institute for Medical Research
Deposited On:2014-08-27
Last Modified:2014-09-01
Downloads:0

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