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Felis catus gammaherpesvirus 1; a widely endemic potential pathogen of domestic cats

Citation

Beatty, JA and Troyer, RM and Carver, S and Barrs, VR and Espinasse, F and Conradi, O and Stutzman-Rodriguez, K and Chan, CC and Tasker, S and Lappin, MR and VandeWoude, S, Felis catus gammaherpesvirus 1; a widely endemic potential pathogen of domestic cats, Virology, 460-461 pp. 100-107. ISSN 0042-6822 (2014) [Refereed Article]

Copyright Statement

Copyright 2014 Elsevier Inc.

DOI: doi:10.1016/j.virol.2014.05.007

Abstract

Felis catus gammaherpesvirus 1 (FcaGHV1), recently discovered in the USA, was detected in domestic cats in Australia (11.4%, 95% confidence interval 5.9–19.1, n=110) and Singapore (9.6%, 95% confidence interval 5.9–14.6, n=176) using qPCR. FcaGHV1 qPCR positive cats were 2.8 times more likely to be sick than healthy. Risk factors for FcaGHV1 detection included being male, increasing age and coinfection with pathogenic retroviruses, feline immunodeficiency virus (FIV) or feline leukaemia virus. FcaGHV1 DNA was detected in multiple tissues from infected cats with consistently high virus loads in the small intestine. FcaGHV1 viral load was significantly higher in FIV-infected cats compared with matched controls, mimicking increased Epstein–Barr virus loads in human immunodeficiency virus-infected humans. FcaGHV1 is endemic in distant geographic regions and is associated with being sick and with coinfections. Horizontal transmission of FcaGHV1 is supported, with biting being a plausible route. A pathogenic role for FcaGHV1 in domestic cats is supported.

Item Details

Item Type:Refereed Article
Keywords:gamaherpesvirus, feline, domestic cat, molecular epidemiology, disease ecology, copathogen, transmission
Research Division:Biological Sciences
Research Group:Evolutionary Biology
Research Field:Host-Parasite Interactions
Objective Division:Environment
Objective Group:Control of Pests, Diseases and Exotic Species
Objective Field:Control of Pests, Diseases and Exotic Species at Regional or Larger Scales
Author:Carver, S (Dr Scott Carver)
ID Code:93923
Year Published:2014
Web of Science® Times Cited:13
Deposited By:Zoology
Deposited On:2014-08-22
Last Modified:2017-11-01
Downloads:0

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