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Felis catus gammaherpesvirus 1; a widely endemic potential pathogen of domestic cats
Citation
Beatty, JA and Troyer, RM and Carver, S and Barrs, VR and Espinasse, F and Conradi, O and Stutzman-Rodriguez, K and Chan, CC and Tasker, S and Lappin, MR and VandeWoude, S, Felis catus gammaherpesvirus 1; a widely endemic potential pathogen of domestic cats, Virology, 460-461 pp. 100-107. ISSN 0042-6822 (2014) [Refereed Article]
Copyright Statement
Copyright 2014 Elsevier Inc.
DOI: doi:10.1016/j.virol.2014.05.007
Abstract
Felis catus gammaherpesvirus 1 (FcaGHV1), recently discovered in the USA, was detected in domestic cats in Australia (11.4%, 95% confidence interval 5.9–19.1, n=110) and Singapore (9.6%, 95% confidence interval 5.9–14.6, n=176) using qPCR. FcaGHV1 qPCR positive cats were 2.8 times more likely to be sick than healthy. Risk factors for FcaGHV1 detection included being male, increasing age and coinfection with pathogenic retroviruses, feline immunodeficiency virus (FIV) or feline leukaemia virus. FcaGHV1 DNA was detected in multiple tissues from infected cats with consistently high virus loads in the small intestine. FcaGHV1 viral load was significantly higher in FIV-infected cats compared with matched controls, mimicking increased Epstein–Barr virus loads in human immunodeficiency virus-infected humans. FcaGHV1 is endemic in distant geographic regions and is associated with being sick and with coinfections. Horizontal transmission of FcaGHV1 is supported, with biting being a plausible route. A pathogenic role for FcaGHV1 in domestic cats is supported.
Item Details
Item Type: | Refereed Article |
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Keywords: | gamaherpesvirus, feline, domestic cat, molecular epidemiology, disease ecology, copathogen, transmission |
Research Division: | Biological Sciences |
Research Group: | Evolutionary biology |
Research Field: | Host-parasite interactions |
Objective Division: | Environmental Management |
Objective Group: | Terrestrial systems and management |
Objective Field: | Control of pests, diseases and exotic species in terrestrial environments |
UTAS Author: | Carver, S (Dr Scott Carver) |
ID Code: | 93923 |
Year Published: | 2014 |
Web of Science® Times Cited: | 27 |
Deposited By: | Zoology |
Deposited On: | 2014-08-22 |
Last Modified: | 2017-11-01 |
Downloads: | 0 |
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