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Mass effect and signal intensity alteration in the suprapatellar fat pad: associations with knee symptoms and structure

Citation

Wang, J and Han, W and Wang, X and Pan, F and Liu, Z and Halliday, A and Jin, X and Antony, B and Cicuttini, F and Jones, G and Ding, C, Mass effect and signal intensity alteration in the suprapatellar fat pad: associations with knee symptoms and structure, Osteoarthritis and Cartilage, 22, (10) pp. 1619-1626. ISSN 1063-4584 (2014) [Refereed Article]

Copyright Statement

Copyright 2014 Osteoarthritis Research Society International

DOI: doi:10.1016/j.joca.2014.05.018

Abstract

Objective: To describe cross-sectional associations between mass effect or signal intensity alteration of the suprapatellar fat pad (SPFP) with knee symptoms and structure in older adults.

Methods: A cross-sectional sample of 904 randomly selected subjects (mean 62.4 years, 49.9% female) was studied. T1- or T2-weighted fat suppressed magnetic resonance imaging (MRI) was used to assess mass effect or signal intensity alteration of SPFP, cartilage volume, cartilage defects, and bone marrow lesions (BMLs). Knee pain was assessed by self-administered Western Ontario McMaster Osteoarthritis Index (WOMAC) questionnaire. The Osteoarthritis Research Society International (OARSI) atlas was used to assess knee osteophyte, joint space narrowing (JSN) and radiographic osteoarthritis (ROA). Univariable and multivariable linear or logistic regression analyses were used to examine the associations.

Results: After adjustment for confounders including age, sex, body mass index (BMI), disease status, tibial bone area and/or ROA, the presence of SPFP mass effect was significantly associated with any knee pain (OR: 2.39; 95% confidence interval (CI): 1.54, 3.70) and ROA (OR: 2.10; 95% CI: 1.33, 3.31) but not with cartilage volume, cartilage defects or BMLs. The presence of SPFP signal intensity alteration was significantly associated with any knee pain (OR: 1.90; 95% CI: 1.43, 2.53), ROA (OR: 1.83; 95% CI: 1.37, 2.45), any BMLs (OR: 1.55; 95% CI: 1.17, 2.06) but not with cartilage volume and cartilage defects. Significant associations with knee pain and BMLs were more evident in subjects with ROA. Presence of SPFP mass effect and/or signal intensity alteration combined was associated with any tibial cartilage defects (OR: 1.45; 95% CI: 1.04, 2.04).

Conclusions: SPFP mass effect and/or signal intensity alterations are deleteriously associated with knee pain, radiographic OA and BMLs in this cross-sectional study, suggesting that SPFP abnormalities may contribute to pain and structural abnormalities in the knee.

Item Details

Item Type:Refereed Article
Keywords:osteoarthritis, pain, suprapatellar fat pad
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Rheumatology and Arthritis
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Skeletal System and Disorders (incl. Arthritis)
Author:Wang, J (Dr Jue Wang)
Author:Han, W (Dr Weiyu Han)
Author:Wang, X (Associate Professor Xia Wang)
Author:Pan, F (Professor Faming Pan)
Author:Liu, Z (Dr Zhenhua Liu)
Author:Jin, X (Mr Xingzhong Jin)
Author:Antony, B (Mr Benny Eathakkattu Antony)
Author:Jones, G (Professor Graeme Jones)
Author:Ding, C (Professor Chang-Hai Ding)
ID Code:93912
Year Published:2014
Web of Science® Times Cited:7
Deposited By:Menzies Institute for Medical Research
Deposited On:2014-08-21
Last Modified:2017-11-02
Downloads:0

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