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Plasma rich in growth factors (PRGF-Endoret) reduces neuropathologic hallmarks and improves cognitive functions in an Alzheimer's disease mouse model
Citation
Anitua, E and Pascual, C and Antequera, D and Bolos, M and Padilla, S and Orive, G and Carro, E, Plasma rich in growth factors (PRGF-Endoret) reduces neuropathologic hallmarks and improves cognitive functions in an Alzheimer's disease mouse model, Neurobiology of Aging: Experimental and Clinical Research, 35, (7) pp. 1582-1595. ISSN 0197-4580 (2014) [Refereed Article]
Copyright Statement
Copyright 2014 Elsevier Inc.
DOI: doi:10.1016/j.neurobiolaging.2014.01.009
Abstract
Impaired growth factor function is thought to drive many of the alterations observed in Alzheimer's disease (AD) patients. Endogenous regenerative technology, PRGF (plasma rich in growth factor)-Endoret, is designed for the delivery of a complex pool of patient's own active morphogens that may stimulate tissue regeneration. We obtained and characterized PRGF-Endoret preparations from human blood. We used, as experimental approach in vivo, APP/PS1 mice, characterized by age-dependent brain amyloid-β (Aβ) accumulation. Intranasal administration of PRGF-Endoret to APP/PS1 mice resulted in an important decrease in brain Aβ deposition and tau phosphorylation. PRGF-Endoret-treated APP/PS1 mice also showed decreased astrocyte reactivity, and prevented protein synaptic loss. In vitro approaches demonstrated that PRGF-Endoret treatment modulated astrocyte activation, reducing inflammatory responses, and promoted Aβ degradation. Furthermore, PRGF-Endoret stimulated global improvements in anxiety, learning, and memory behaviors. Our findings show that PRGF-Endoret exerts multifunctional and complementary effects that result in the reversal of the broad range of cognitive deficits in AD, suggesting that PRGF-Endoret may hold promise as an innovative therapy in AD.
Item Details
Item Type: | Refereed Article |
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Keywords: | Alzheimer’s disease, PRGF-Endoret, Intranasal administration, Ab degradation, Cognition, Astrocytes, Transgenic mice, Cognitive impairment |
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Neurosciences |
Research Field: | Cellular nervous system |
Objective Division: | Expanding Knowledge |
Objective Group: | Expanding knowledge |
Objective Field: | Expanding knowledge in the biological sciences |
UTAS Author: | Bolos, M (Dr Marta Bolos Jurado) |
ID Code: | 93867 |
Year Published: | 2014 |
Web of Science® Times Cited: | 30 |
Deposited By: | Menzies Institute for Medical Research |
Deposited On: | 2014-08-20 |
Last Modified: | 2014-08-27 |
Downloads: | 0 |
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