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Epithelial-mesenchymal transition as a fundamental underlying pathogenic process in COPD airways: fibrosis, remodeling and cancer

Citation

Nowrin, K and Sohal, SS and Peterson, G and Patel, R and Walters, EH, Epithelial-mesenchymal transition as a fundamental underlying pathogenic process in COPD airways: fibrosis, remodeling and cancer, Expert Reviews in Respiratory Medicine, 8, (5) pp. 547-559. ISSN 1747-6348 (2014) [Refereed Article]

Copyright Statement

Copyright 2014 Informa UK Ltd.

DOI: doi:10.1586/17476348.2014.948853

Abstract

Chronic obstructive pulmonary disease (COPD) is a complex condition, frequently with a mix of airway and lung parenchymal damage. However, the earliest changes are in the small airways, where most of the airflow limitation occurs. The pathology of small airway damage seems to be wall fibrosis and obliteration, but the whole airway is involved in a ‘field effect’. Our novel observations on active epithelial-mesenchymal transition (EMT) in the airways of smokers, particularly in those with COPD, are changing the understanding of this airway pathology and the aetiology of COPD. EMT involves a cascade of regulatory changes that destabilise the epithelium with a motile and mesenchymal epithelial cell phenotype emerging. One important manifestation of EMT activity involves up-regulation of specific key transcription factors (TFs), such as Smads, Twist, and β-catenin. Such TFs can be used as EMT biomarkers, in recognisable patterns reflecting the potential major drivers of the process; for example, TGFβ, Wnt, and integrin-linked kinase systems. Thus, understanding the relative changes in TF activity during EMT may provide rich information on the mechanisms driving this whole process, and how they may change over time and with therapy. We have sought to review the current literature on EMT and the relative expression of specific TF activity, to define the networks likely to be involved in a similar process in the airways of patients with smoking-related COPD.

Item Details

Item Type:Refereed Article
Keywords:COPD, epithelial-mesenchymal transition, Smads, smoking, transcription factors, b-catenin
Research Division:Medical and Health Sciences
Research Group:Cardiorespiratory Medicine and Haematology
Research Field:Respiratory Diseases
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Respiratory System and Diseases (incl. Asthma)
Author:Nowrin, K (Ms Kaosia Nowrin)
Author:Sohal, SS (Dr Sukhwinder Sohal)
Author:Peterson, G (Professor Gregory Peterson)
Author:Patel, R (Dr Rahul Patel)
Author:Walters, EH (Professor Haydn Walters)
ID Code:93827
Year Published:2014
Web of Science® Times Cited:20
Deposited By:Medicine (Discipline)
Deposited On:2014-08-19
Last Modified:2017-11-03
Downloads:0

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