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Pathological changes in the COPD lung mesenchyme - Novel lessons learned from in vitro and in vivo studies

Citation

Ojo, O and Lagan, AL and Rajendran, V and Spanjer, A and Chen, L and Sohal, SS and Heijink, I and Jones, R and Maarsingh, H and Hackett, TL, Pathological changes in the COPD lung mesenchyme - Novel lessons learned from in vitro and in vivo studies, Pulmonary Pharmacology and Therapeutics, 29, (2) pp. 121-128. ISSN 1094-5539 (2014) [Refereed Article]

Copyright Statement

Copyright 2014 Elsevier

DOI: doi:10.1016/j.pupt.2014.04.004

Abstract

Chronic obstructive pulmonary disease (COPD) is currently the fourth leading cause of death worldwide and, in contrast to the trend for cardiovascular diseases, mortality rates still continue to climb. This increase is in part due to an aging population, being expanded by the "Baby boomer" generation who grew up when smoking rates were at their peak and by people in developing countries living longer. Sadly, there has been a disheartening lack of new therapeutic approaches to counteract the progressive decline in lung function associated with the disease that leads to disability and death. COPD is characterized by irreversible chronic airflow limitation that is caused by emphysematous destruction of lung elastic tissue and/or obstruction in the small airways due to occlusion of their lumen by inflammatory mucus exudates, narrowing and obliteration. These lesions are mainly produced by the response of the tissue to the repetitive inhalational injury inflicted by noxious gases, including cigarette smoke, which involves interaction between infiltrating inflammatory immune cells, resident cells (e.g. epithelial cells and fibroblasts) and the extra cellular matrix. This interaction leads to tissue destruction and airway remodeling with changes in elastin and collagen, such that the epithelial–mesenchymal trophic unit is dysregulated in both the disease pathologies. This review focuses on: 1 – novel inflammatory and remodeling factors that are altered in COPD; 2 – in vitro and in vivo models to understand the mechanism whereby the extra cellular matrix environment in altered in COPD; and 3 – COPD in the context of wound-repair tissue responses, with a focus on the regulation of mesenchymal cell fate and phenotype.

Item Details

Item Type:Refereed Article
Keywords:chronic obstructive pulmonary disease, inflammation, extra cellular matrix, epithelialemesenchymal interactions, novel pharmacological targets
Research Division:Medical and Health Sciences
Research Group:Cardiorespiratory Medicine and Haematology
Research Field:Respiratory Diseases
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Respiratory System and Diseases (incl. Asthma)
Author:Chen, L (Dr Ling Chen)
Author:Sohal, SS (Dr Sukhwinder Sohal)
ID Code:93824
Year Published:2014
Web of Science® Times Cited:14
Deposited By:Medicine (Discipline)
Deposited On:2014-08-19
Last Modified:2017-11-02
Downloads:0

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