eCite Digital Repository

The clinical significance, natural history and predictors of bone marrow lesion change over eight years

Citation

Foong, YC and Khan, HI and Blizzard, L and Ding, C and Cicuttini, F and Jones, G and Aitken, D, The clinical significance, natural history and predictors of bone marrow lesion change over eight years, Arthritis Research & Therapy, 16, (4) Article R149. ISSN 1478-6362 (2014) [Refereed Article]


Preview
PDF
251Kb
  

Copyright Statement

Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) http://creativecommons.org/licenses/by/4.0/

DOI: doi:10.1186/ar4611

Abstract

Introduction: There is increasing evidence to suggest that bone marrow lesions (BMLs) play a key role in the pathogenesis of osteoarthritis (OA). However, there is a lack of long term data. The aim of this study was to describe the natural history of knee BMLs, their association with knee pain and examine predictors of BML change over eight years.Methods: A total of 198 subjects (109 adult offspring of subjects who had a knee replacement and 89 community-based controls) were studied. Knee pain and BML size were assessed at two and ten year visits.Results: At the two year visit, 64% of participants (n = 127) had 229 BMLs (34% patella, 26% femoral and 40% tibial). Over eight years, 24% (55/229) increased in size, 55% (125/229) remained stable and 21% (49/229) decreased in size or resolved completely. Of the participants without BMLs at baseline, 52% (37/71) developed incident BMLs.After adjusting for confounders, eight year change in total BML size was associated with change in knee pain in offspring (β = 2.50, 95% confidence interval (CI) 0.96 to 4.05) but not controls. This association was stronger in males. Incident BMLs were associated with increase in pain (β = 3.60, 95% CI 1.14 to 6.05). Body mass index (BMI) and strenuous activity (but not radiographic osteoarthritis or smoking) were associated with an increase in BML size.Conclusion: In this midlife cohort, the proportion of BMLs increasing in size was similar to those decreasing in size with the majority remaining stable. Change in BMLs was predicted by BMI and strenuous activity. An increase in BML size or a new BML resulted in an increase in pain especially in males and those with a family history of OA. © 2014 Foong et al.; licensee BioMed Central Ltd.

Item Details

Item Type:Refereed Article
Keywords:bone marrow lesions, osteoarthritis
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Rheumatology and Arthritis
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Skeletal System and Disorders (incl. Arthritis)
Author:Foong, YC (Dr Yi Chao Foong)
Author:Khan, HI (Dr Hussain Khan)
Author:Blizzard, L (Associate Professor Leigh Blizzard)
Author:Ding, C (Professor Chang-Hai Ding)
Author:Jones, G (Professor Graeme Jones)
Author:Aitken, D (Dr Dawn Aitken)
ID Code:93764
Year Published:2014
Web of Science® Times Cited:11
Deposited By:Menzies Institute for Medical Research
Deposited On:2014-08-14
Last Modified:2017-11-02
Downloads:210 View Download Statistics

Repository Staff Only: item control page