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Insulin-induced changes in microvascular vasomotion and capillary recruitment are associated in humans

Citation

De Boer, MP and Meijer, RI and Newman, J and Stehouwer, CDA and Eringa, EC and Smulders, YM and Serne, EH, Insulin-induced changes in microvascular vasomotion and capillary recruitment are associated in humans, Microcirculation, 21, (5) pp. 380-387. ISSN 1073-9688 (2014) [Refereed Article]

Copyright Statement

Copyright 2014 John Wiley & Sons Ltd

DOI: doi:10.1111/micc.12114

Abstract

Objective: Insulin-induced capillary recruitment is considered a significant regulator of overall insulin-stimulated glucose uptake. Insulin's action to recruit capillaries has been hypothesized to involve insulin-induced changes in vasomotion. Data directly linking vasomotion to capillary perfusion, however, are presently lacking. We, therefore, investigated whether insulin's actions on capillary recruitment and vasomotion were interrelated in a group of healthy individuals. We further assessed the role of capillary recruitment in the association between vasomotion and insulin-mediated glucose uptake. Methods: Changes in vasomotion and capillary density were determined by LDF and capillary videomicroscopy in skin, respectively, before and during a hyperinsulinemic euglycemic clamp in 19 healthy volunteers. Results: Insulin-induced increase in the neurogenic vasomotion domain was positively related to insulin-augmented capillary recruitment (r = 0.51, p = 0.04), and both parameters were related to insulin-mediated glucose uptake (r = 0.47, p = 0.06 and r = 0.73, p = 0.001, respectively). The change in insulin-augmented capillary recruitment could, at least statistically, largely explain the association between the neurogenic domain and insulin-mediated glucose uptake. Conclusions: Insulin-induced changes in vasomotion and capillary recruitment are associated in healthy volunteers. These data suggest that insulin's action to recruit capillaries may in part involve action on the neurogenic vasomotion domain, thereby enhancing capillary perfusion and glucose uptake. © 2014 John Wiley & Sons Ltd.

Item Details

Item Type:Refereed Article
Keywords:vasomotion, capillary recruitment, insulin sensitivity
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Endocrinology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Diabetes
Author:Newman, J (Dr John Newman)
ID Code:93741
Year Published:2014
Web of Science® Times Cited:5
Deposited By:Menzies Institute for Medical Research
Deposited On:2014-08-14
Last Modified:2015-02-11
Downloads:0

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