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Therapeutic approaches to disease modifying therapy for multiple sclerosis in adults: An Australian and New Zealand perspective Part 2 New and emerging therapies and their efficacy

Citation

Broadley, SA and Barnett, MH and Boggild, M and Brew, BJ and Butzkueven, H and Heard, R and Hodgkinson, S and Kermode, AG and Lechner-Scott, J and Macdonell, RAL and Marriott, M and Mason, DF and Parratt, J and Reddel, SW and Shaw, CP and Slee, M and Spies, J and Taylor, BV and Carroll, WM and Kilpatrick, TJ and King, J and McCombe, PA and Pollard, JD and Willoughby, E, Therapeutic approaches to disease modifying therapy for multiple sclerosis in adults: An Australian and New Zealand perspective Part 2 New and emerging therapies and their efficacy, Journal of Clinical Neuroscience, 21, (11) pp. 1847-1856. ISSN 0967-5868 (2014) [Refereed Article]

Copyright Statement

Copyright 2014 Elsevier

DOI: doi:10.1016/j.jocn.2014.01.018

Abstract

In Part 2 of this three part review of multiple sclerosis (MS) treatment with a particular focus on the Australian and New Zealand perspective, we review the newer therapies that have recently become available and emerging therapies that have now completed phase III clinical trial programs. We go on to compare the relative efficacies of these newer and emerging therapies alongside the existing therapies. The effectiveness of β-interferon in the treatment of different stages and the different disease courses of MS is critically reviewed with the conclusion that the absolute level of response in term of annualised relapse rates (where relapses occur) and MRI activity are similar, but are disappointing in terms of sustained disability progression for progressive forms of the disease. Finally we review the controversial area of combination therapy for MS. Whilst it remains the case that we have no cure or means of preventing MS, we do have a range of effective therapies that when used appropriately and early in the disease course can have a significant impact on short term and longer term outcomes. Crown Copyright © 2014.

Item Details

Item Type:Refereed Article
Keywords:Evidence-based medicine, Guideline, Multiple Sclerosis, Review, Treatment
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Central Nervous System
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Nervous System and Disorders
Author:Taylor, BV (Professor Bruce Taylor)
ID Code:93264
Year Published:2014
Web of Science® Times Cited:3
Deposited By:Menzies Institute for Medical Research
Deposited On:2014-07-23
Last Modified:2017-11-06
Downloads:0

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