eCite Digital Repository

Therapeutic approaches to disease modifying therapy for multiple sclerosis in adults: An Australian and New Zealand perspective Part 1 Historical and established therapies

Citation

Broadley, SA and Barnett, MH and Boggild, M and Brew, BJ and Butzkueven, H and Heard, R and Hodgkinson, S and Kermode, AG and Lechner-Scott, J and Macdonell, RAL and Marriott, M and Mason, DF and Parratt, J and Reddel, SW and Shaw, CP and Slee, M and Spies, J and Taylor, BV and Carroll, WM and Kilpatrick, TJ and King, J and McCombe, PA and Pollard, JD and Willoughby, E, Therapeutic approaches to disease modifying therapy for multiple sclerosis in adults: An Australian and New Zealand perspective Part 1 Historical and established therapies, Journal of Clinical Neuroscience, 21, (11) pp. 1835-1846. ISSN 0967-5868 (2014) [Refereed Article]

Copyright Statement

Copyright 2014 Elsevier

DOI: doi:10.1016/j.jocn.2014.01.016

Abstract

Multiple sclerosis (MS) is a potentially life-changing immune mediated disease of the central nervous system. Until recently, treatment has been largely confined to acute treatment of relapses, symptomatic therapies and rehabilitation. Through persistent efforts of dedicated physicians and scientists around the globe for 160 years, a number of therapies that have an impact on the long term outcome of the disease have emerged over the past 20 years. In this three part series we review the practicalities, benefits and potential hazards of each of the currently available and emerging treatment options for MS. We pay particular attention to ways of abrogating the risks of these therapies and provide advice on the most appropriate indications for using individual therapies. In Part 1 we review the history of the development of MS therapies and its connection with the underlying immunobiology of the disease. The established therapies for MS are reviewed in detail and their current availability and indications in Australia and New Zealand are summarised. We examine the evidence to support their use in the treatment of MS.

Item Details

Item Type:Refereed Article
Keywords:Evidence-based medicine, Guideline, Multiple Sclerosis, Review, Treatment
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Central Nervous System
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Nervous System and Disorders
Author:Taylor, BV (Professor Bruce Taylor)
ID Code:93263
Year Published:2014
Web of Science® Times Cited:4
Deposited By:Menzies Institute for Medical Research
Deposited On:2014-07-23
Last Modified:2017-11-06
Downloads:0

Repository Staff Only: item control page