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Therapeutic approaches to disease modifying therapy for multiple sclerosis in adults: An Australian and New Zealand perspective Part 1 Historical and established therapies

journal contribution
posted on 2023-05-18, 02:12 authored by Broadley, SA, Barnett, MH, Boggild, M, Brew, BJ, Butzkueven, H, Heard, R, Hodgkinson, S, Kermode, AG, Lechner-Scott, J, Macdonell, RAL, Marriott, M, Mason, DF, Parratt, J, Reddel, SW, Shaw, CP, Slee, M, Spies, J, Bruce TaylorBruce Taylor, Carroll, WM, Kilpatrick, TJ, King, J, McCombe, PA, Pollard, JD, Willoughby, E
Multiple sclerosis (MS) is a potentially life-changing immune mediated disease of the central nervous system. Until recently, treatment has been largely confined to acute treatment of relapses, symptomatic therapies and rehabilitation. Through persistent efforts of dedicated physicians and scientists around the globe for 160 years, a number of therapies that have an impact on the long term outcome of the disease have emerged over the past 20 years. In this three part series we review the practicalities, benefits and potential hazards of each of the currently available and emerging treatment options for MS. We pay particular attention to ways of abrogating the risks of these therapies and provide advice on the most appropriate indications for using individual therapies. In Part 1 we review the history of the development of MS therapies and its connection with the underlying immunobiology of the disease. The established therapies for MS are reviewed in detail and their current availability and indications in Australia and New Zealand are summarised. We examine the evidence to support their use in the treatment of MS.

History

Publication title

Journal of Clinical Neuroscience

Volume

21

Issue

11

Pagination

1835-1846

ISSN

0967-5868

Department/School

Menzies Institute for Medical Research

Publisher

Churchill Livingstone

Place of publication

Journal Production Dept, Robert Stevenson House, 1-3 Baxters Place, Leith Walk, Edinburgh, Scotland, Midlothian, Eh1 3Af

Rights statement

Copyright 2014 Elsevier

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

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