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Aortic reservoir pressure corresponds to cyclic changes in aortic volume: physiological validation in humans

Citation

Schultz, MG and Davies, JE and Hardikar, A and Pitt, S and Moraldo, M and Dhutia, N and Hughes, AD and Sharman, JE, Aortic reservoir pressure corresponds to cyclic changes in aortic volume: physiological validation in humans, Arteriosclerosis, Thrombosis, and Vascular Biology, 34, (7) pp. 1597-1603. ISSN 1079-5642 (2014) [Refereed Article]


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Copyright Statement

Copyright 2014 American Heart Association, Inc.

DOI: doi:10.1161/ATVBAHA.114.303573

Abstract

OBJECTIVE: Aortic reservoir pressure indices independently predict cardiovascular events and mortality. Despite this, there has never been a study in humans to determine whether the theoretical principles of the mathematically derived aortic reservoir pressure (RPderived) and excess pressure (XPderived) model have a real physiological basis. This study aimed to directly measure the aortic reservoir (ARdirect; by cyclic change in aortic volume) and determine its relationship with RPderived, XPderived, and aortic blood pressure (BP). APPROACH AND RESULTS: Ascending aortic BP and Doppler flow velocity were recorded via intra-arterial wire in 10 men (aged 6212 years) during coronary artery bypass surgery. Simultaneous ascending aortic transesophageal echocardiography was used to measure ARdirect. Published mathematical formulae were used to determine RPderived and XPderived. ARdirect was strongly and linearly related to RPderived during systole (r=0.988; P<0.001) and diastole (r=0.985; P<0.001). Peak cross-correlation (r=0.98) occurred at a phase lag of 0.004 s into the cardiac cycle, suggesting close temporal agreement between waveforms. The relationship between aortic BP and ARdirect was qualitatively similar to the cyclic relationship between aortic BP and RPderived, with peak cross-correlations occurring at identical phase lags (ARdirect versus aortic BP, r=0.96 at 0.06 s; RPderived versus aortic BP, r=0.98 at 0.06 s). CONCLUSIONS: RPderived is highly correlated with changes in proximal aortic volume, consistent with its physiological interpretation as corresponding to the instantaneous volume of blood stored in the aorta. Thus, aortic reservoir pressure should be considered in the interpretation of the central BP waveform.

Item Details

Item Type:Refereed Article
Keywords:aorta, vascular stiffness
Research Division:Medical and Health Sciences
Research Group:Cardiorespiratory Medicine and Haematology
Research Field:Cardiology (incl. Cardiovascular Diseases)
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Cardiovascular System and Diseases
Author:Schultz, MG (Dr Martin Schultz)
Author:Hardikar, A (Dr Ashutosh Hardikar)
Author:Sharman, JE (Professor James Sharman)
ID Code:92693
Year Published:2014
Web of Science® Times Cited:19
Deposited By:Menzies Institute for Medical Research
Deposited On:2014-06-25
Last Modified:2017-10-31
Downloads:0

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