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Metabolomics in hypertension

Citation

Nikolic, SB and Sharman, JE and Adams, MJ and Edwards, LM, Metabolomics in hypertension, Journal of Hypertension, 32, (6) pp. 1159-1169. ISSN 0263-6352 (2014) [Refereed Article]

Copyright Statement

Copyright 2014 Lippincott Williams & Wilkins

DOI: doi:10.1097/HJH.0000000000000168

Abstract

Hypertension is the most prevalent chronic medical condition and a major risk factor for cardiovascular morbidity and mortality. In the majority of hypertensive cases, the underlying cause of hypertension cannot be easily identified because of the heterogeneous, polygenic and multi-factorial nature of hypertension. Metabolomics is a relatively new field of research that has been used to evaluate metabolic perturbations associated with disease, identify disease biomarkers and to both assess and predict drug safety and efficacy. Metabolomics has been increasingly used to characterize risk factors for cardiovascular disease, including hypertension, and it appears to have significant potential for uncovering mechanisms of this complex disease. This review details the analytical techniques, pre-analytical steps and study designs used in metabolomics studies, as well as the emerging role for metabolomics in gaining mechanistic insights into the development of hypertension. Suggestions as to the future direction for metabolomics research in the field of hypertension are also proposed. © 2014 Wolters Kluwer Health | Lippincott Williams Wilkins.

Item Details

Item Type:Refereed Article
Keywords:biomarkers, blood pressure, mass spectrometry, metabolomics, NMR spectroscopy, pharmacometabolomics
Research Division:Medical and Health Sciences
Research Group:Cardiorespiratory Medicine and Haematology
Research Field:Cardiology (incl. Cardiovascular Diseases)
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Cardiovascular System and Diseases
Author:Nikolic, SB (Mrs Sonja Nikolic)
Author:Sharman, JE (Professor James Sharman)
Author:Adams, MJ (Dr Murray Adams)
ID Code:92474
Year Published:2014
Web of Science® Times Cited:13
Deposited By:Menzies Institute for Medical Research
Deposited On:2014-06-19
Last Modified:2015-03-30
Downloads:0

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