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Associations between vitamin D receptor gene polymorphisms and osteoarthritis: an updated meta-analysis


Zhu, Z and Jin, X-Z and Zhang, W and Chen, M and Ye, D-Q and Zhai, Y and Dong, F-L and Shen, C-L and Ding, C, Associations between vitamin D receptor gene polymorphisms and osteoarthritis: an updated meta-analysis, Rheumatology: The Interdisciplinary Concept, 53, (6) pp. 998-1008. ISSN 0080-2727 (2014) [Refereed Article]

Copyright Statement

Copyright 2014 the authors

DOI: doi:10.1093/rheumatology/ket418


Objective: Vitamin D receptor (VDR) gene polymorphisms may be associated with the risk of OA, however, evidence for this is controversial. This meta-analysis aims to confirm whether VDR gene polymorphisms are associated with OA. Methods: Meta-analyses on the association between OA and VDR ApaI, BsmI, TaqI and FokI polymorphisms were conducted using allele and homozygote contrast and contrasts in the recessive and dominant models. Stratification analyses by different demographic regions (Europe vs Asian) were also performed and pooled odds ratios (ORs) were obtained using the random effects model if the results were heterogeneous.Results. A total of 13 relevant studies involving OA patients (n = 2104) and controls (n = 2939) were included in the analysis. There were significant associations between VDR ApaI polymorphisms and OA in the Asian population (A vs a: OR = 1.16, 95% CI 1.02, 1.32, P = 0.025; AA vs Aa/aa: OR = 1.36, 95% CI 1.04, 1.77, P = 0.025; AA vs aa: OR = 1.35, 95% CI 1.00, 1.80, P = 0.047), but not in the whole population. There was also a statistically significant association between FokI polymorphism and OA (FF vs Ff/ff: OR = 0.65, 95% CI 0.44, 0.95, P = 0.024); however, this result was derived from only two studies. No significant associations were found between VDR TaqI and BsmI polymorphisms and OA. Conclusion: There are modest but statistically significant associations between VDR ApaI polymorphisms and the susceptibility of OA in the Asian population. © The Author 2014. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved.

Item Details

Item Type:Refereed Article
Keywords:vitamin D receptor, osteoarthritis, polymorphisms, meta-analysis
Research Division:Biomedical and Clinical Sciences
Research Group:Clinical sciences
Research Field:Rheumatology and arthritis
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Zhu, Z (Mr Zhaohua Zhu)
UTAS Author:Jin, X-Z (Mr Xingzhong Jin)
UTAS Author:Ding, C (Professor Chang-Hai Ding)
ID Code:92393
Year Published:2014
Web of Science® Times Cited:28
Deposited By:Menzies Institute for Medical Research
Deposited On:2014-06-17
Last Modified:2017-11-02

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