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The effect of maternal prenatal smoking and alcohol consumption on the placenta-to-birth weight ratio

Citation

Wang, N and Tikellis, G and Sun, C and Pezic, A and Wang, L and Wells, JCK and Cochrane, J and Ponsonby, A-L and Dwyer, T, The effect of maternal prenatal smoking and alcohol consumption on the placenta-to-birth weight ratio, Placenta, 35, (7) pp. 437-441. ISSN 0143-4004 (2014) [Refereed Article]

Copyright Statement

Copyright 2014 Elsevier Ltd.

DOI: doi:10.1016/j.placenta.2014.04.006

Abstract

BACKGROUND: Maternal influence on fetal growth is mediated through the placenta and this influence may have an implication for the offspring's long-term health. The placenta-to-birth weight ratio has been regarded as an indicator of placental function. However, few studies have examined the effect of maternal lifestyle exposures on the placenta-to-birth weight ratio. This study aims to examine the associations of maternal prenatal smoking and alcohol consumption with the placenta-to-birth weight ratio. METHODS: Data for 7945 term singletons, gestation≥37 weeks, were selected from the Tasmanian Infant Health Survey; a 1988-1995 Australian cohort study. Placenta and birth weight were extracted from birth notification records. RESULTS: Maternal smoking during pregnancy was strongly associated with a 6.77 g/kg higher (95% CI 4.83-8.71) placenta-to-birth weight ratio when compared to non-smoking mothers. Maternal prenatal smoking was associated with lower placental (β = -15.37 g; 95% CI -23.43 to -7.31) and birth weights (β = -205.49 g; 95% CI -232.91 to -178.08). Mothers who consumed alcohol during pregnancy had a lower placenta-to-birth weight ratio (β = -2.07 g/kg; 95% CI -4.01 to -0.12) than mothers who did not consume alcohol. The associations of maternal alcohol consumption during pregnancy with placental and birth weight did not reach statistical significance. DISCUSSION: Maternal prenatal smoking and alcohol consumption may influence fetal growth by either directly or indirectly altering the function of the placenta. CONCLUSIONS: The alteration of the in utero environment induced by smoking and alcohol consumption appears to affect placental and fetal growth in differing ways. Further studies are needed to elucidate the mechanism.

Item Details

Item Type:Refereed Article
Keywords:Placenta, Birthweight, Pregnancy, Maternal smoking, Alcohol
Research Division:Medical and Health Sciences
Research Group:Paediatrics and Reproductive Medicine
Research Field:Foetal Development and Medicine
Objective Division:Health
Objective Group:Public Health (excl. Specific Population Health)
Objective Field:Behaviour and Health
Author:Cochrane, J (Mrs Jennifer Cochrane)
ID Code:92392
Year Published:2014
Web of Science® Times Cited:15
Deposited By:Menzies Institute for Medical Research
Deposited On:2014-06-17
Last Modified:2017-11-06
Downloads:0

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