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A systematic review and meta-analysis of utility-based quality of life for osteoporosis-related conditions

Citation

Si, L and Winzenberg, TM and de Graaff, B and Palmer, AJ, A systematic review and meta-analysis of utility-based quality of life for osteoporosis-related conditions, Osteoporosis International, 25, (8) pp. 1987-1997. ISSN 0937-941X (2014) [Refereed Article]

Copyright Statement

Copyright 2014 Springer

DOI: doi:10.1007/s00198-014-2636-2

Abstract

This study aimed to statistically combine multiple health state utility values (HSUVs) reported in the literature for patients with osteoporosis and osteoporotic fractures. Fracture events were associated with decrements in HSUVs which differed between fracture sites. We have provided summary values for use in future health economics analyses in osteoporosis. Osteoporotic fractures have high financial and health burden. Economic evaluations on osteoporotic fracture prevention have been frequently performed in past decades. One of the challenges in the economic evaluations was to identify consistent health state utility values (HSUVs) to use for osteoporotic fracture-related conditions. The objective of this study was to determine summary measures of multiple HSUVs reported in the literature for patients with osteoporosis and osteoporotic fractures. We performed a systematic review, meta-analysis and meta-regression of published literature that reported HSUVs for osteoporotic fracture-related conditions. There were 62 studies representing 142,477 patients included. In total, 362 HSUVs were identified: 106 for pre-fracture; 89 for post-hip fracture; 130 for post-vertebral fracture and 37 for post-wrist fracture. The pooled HSUVs, using a random-effects model were 0.76 (95 % CI 0.75, 0.77, I 2 = 0.99) for pre-fracture; 0.57 (95 % CI 0.52, 0.63, I 2 = 1) for post-hip fracture; 0.59 (95 % CI 0.55, 0.62, I 2 = 0.99) for post-vertebral facture and 0.72 (95 % CI 0.67, 0.78, I 2 = 1) for post-wrist fracture. Heterogeneities were addressed through meta-regression. HSUVs immediately following hip, vertebral and wrist fractures were 0.31, 0.44 and 0.61, respectively. Patients' HSUVs improved over time following fracture events: HSUVs for the first year after hip, vertebral and wrist fractures were 0.59, 0.55 and 0.78, respectively; and 0.66, 0.66 and 0.81 for subsequent years. Fractures were associated with significant decrements in HSUVs. This study provides a standard set of HSUVs that can be used in health economic assessments in osteoporosis.

Item Details

Item Type:Refereed Article
Keywords:Health state utility value, Osteoporosis, Quality of life, Utilities
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Rheumatology and Arthritis
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Skeletal System and Disorders (incl. Arthritis)
Author:Si, L (Mr Lei Si)
Author:Winzenberg, TM (Professor Tania Winzenberg)
Author:de Graaff, B (Ms Barbara de Graaff)
Author:Palmer, AJ (Professor Andrew Palmer)
ID Code:92292
Year Published:2014
Web of Science® Times Cited:12
Deposited By:Menzies Institute for Medical Research
Deposited On:2014-06-12
Last Modified:2015-02-03
Downloads:0

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