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An adverse lipid profile is associated with disability and progression in disability, in people with MS

Citation

Tettey, P and Simpson Jr, S and Taylor, B and Blizzard, L and Ponsonby, A-L and Dwyer, T and Kostner, K and van der Mei, I, An adverse lipid profile is associated with disability and progression in disability, in people with MS, Multiple Sclerosis Journal, 20, (13) pp. 1737-1744. ISSN 1477-0970 (2014) [Refereed Article]

Copyright Statement

Copyright 2014 the authors

DOI: doi:10.1177/1352458514533162

Abstract

BACKGROUND: There is accumulating data suggesting an association between serum lipids, apolipoproteins and disability in multiple sclerosis (MS). OBJECTIVES: To investigate the associations between serum lipids, apolipoproteins and disability in MS. METHODS: A cohort of 178 participants with clinically-definite MS in southern Tasmania, Australia were prospectively followed from 2002 - 2005, and serum samples were obtained at study entry and at each biannual review, to measure lipid profile and apolipoprotein levels. Associations with disability and annual change in disability were evaluated using linear regression and multilevel mixed-effects linear regression. RESULTS: In the unadjusted analyses, nearly all lipid-related variables were positively associated with Expanded Disability Status Scale (EDSS). After adjustment for confounders, total cholesterol (TC) (p = 0.037), apolipoprotein B (ApoB) (p = 0.003), and the apolipoprotein B to apolipoprotein A-I ratio (ApoB/ApoA-I ratio) (p = 0.018) were independently associated with a higher EDSS. Higher body mass index (BMI) was also independently associated with higher EDSS (p = 0.013). With the progression analysis, the total cholesterol to high density lipoprotein (HDL) ratio (TC/HDL ratio) (p = 0.029) was prospectively associated with subsequent change in EDSS. CONCLUSION: In this prospective population-based cohort study, an adverse lipid profile was associated with high levels of MS disability and disease progression. Improving serum lipids may be beneficial for MS patients, to potentially improve clinical outcomes and vascular comorbidities.

Item Details

Item Type:Refereed Article
Keywords:Apolipoprotein, body mass index, cholesterol, disability, lipid profile, multiple sclerosis, progression
Research Division:Medical and Health Sciences
Research Group:Public Health and Health Services
Research Field:Epidemiology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Nervous System and Disorders
Author:Tettey, P (Mr Prudence Tettey)
Author:Simpson Jr, S (Dr Steve Simpson JR)
Author:Taylor, B (Professor Bruce Taylor)
Author:Blizzard, L (Associate Professor Leigh Blizzard)
Author:van der Mei, I (Associate Professor Ingrid van der Mei)
ID Code:92229
Year Published:2014
Web of Science® Times Cited:21
Deposited By:Menzies Institute for Medical Research
Deposited On:2014-06-10
Last Modified:2017-11-02
Downloads:0

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