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An adverse lipid profile is associated with disability and progression in disability, in people with MS
Citation
Tettey, P and Simpson Jr, S and Taylor, B and Blizzard, L and Ponsonby, A-L and Dwyer, T and Kostner, K and van der Mei, I, An adverse lipid profile is associated with disability and progression in disability, in people with MS, Multiple Sclerosis Journal, 20, (13) pp. 1737-1744. ISSN 1477-0970 (2014) [Refereed Article]
Copyright Statement
Copyright 2014 the authors
DOI: doi:10.1177/1352458514533162
Abstract
BACKGROUND:
There is accumulating data suggesting an association between serum lipids, apolipoproteins and disability in multiple sclerosis (MS).
OBJECTIVES:
To investigate the associations between serum lipids, apolipoproteins and disability in MS.
METHODS:
A cohort of 178 participants with clinically-definite MS in southern Tasmania, Australia were prospectively followed from 2002 - 2005, and serum samples were obtained at study entry and at each biannual review, to measure lipid profile and apolipoprotein levels. Associations with disability and annual change in disability were evaluated using linear regression and multilevel mixed-effects linear regression.
RESULTS:
In the unadjusted analyses, nearly all lipid-related variables were positively associated with Expanded Disability Status Scale (EDSS). After adjustment for confounders, total cholesterol (TC) (p = 0.037), apolipoprotein B (ApoB) (p = 0.003), and the apolipoprotein B to apolipoprotein A-I ratio (ApoB/ApoA-I ratio) (p = 0.018) were independently associated with a higher EDSS. Higher body mass index (BMI) was also independently associated with higher EDSS (p = 0.013). With the progression analysis, the total cholesterol to high density lipoprotein (HDL) ratio (TC/HDL ratio) (p = 0.029) was prospectively associated with subsequent change in EDSS.
CONCLUSION:
In this prospective population-based cohort study, an adverse lipid profile was associated with high levels of MS disability and disease progression. Improving serum lipids may be beneficial for MS patients, to potentially improve clinical outcomes and vascular comorbidities.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | Apolipoprotein, body mass index, cholesterol, disability, lipid profile, multiple sclerosis, progression |
| Research Division: | Medical and Health Sciences |
| Research Group: | Public Health and Health Services |
| Research Field: | Epidemiology |
| Objective Division: | Health |
| Objective Group: | Clinical Health (Organs, Diseases and Abnormal Conditions) |
| Objective Field: | Nervous System and Disorders |
| Author: | Tettey, P (Mr Prudence Tettey) |
| Author: | Simpson Jr, S (Dr Steve Simpson JR) |
| Author: | Taylor, B (Professor Bruce Taylor) |
| Author: | Blizzard, L (Professor Leigh Blizzard) |
| Author: | van der Mei, I (Associate Professor Ingrid van der Mei) |
| ID Code: | 92229 |
| Year Published: | 2014 |
| Web of Science® Times Cited: | 27 |
| Deposited By: | Menzies Institute for Medical Research |
| Deposited On: | 2014-06-10 |
| Last Modified: | 2017-11-02 |
| Downloads: | 0 |
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