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Insights into the physiological function of the β-amyloid precursor protein: beyond Alzheimer's disease
Citation
Dawkins, E and Small, DH, Insights into the physiological function of the β-amyloid precursor protein: beyond Alzheimer's disease, Journal of Neurochemistry, 129, (5) pp. 756-769. ISSN 0022-3042 (2014) [Refereed Article]
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Copyright Statement
Copyright 2014 The Authors-This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, (CC BY-NC-ND 2.0 AU) which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modi!cations or adaptations are made.
Abstract
The β-amyloid precursor protein (APP) has been extensively studied for its role as the precursor of the β-amyloid protein (Aβ) of Alzheimer's disease. However, the normal function of APP remains largely unknown. This article reviews studies on the structure, expression and post-translational processing of APP, as well as studies on the effects of APP in vitro and in vivo. We conclude that the published data provide strong evidence that APP has a trophic function. APP is likely to be involved in neural stem cell development, neuronal survival, neurite outgrowth and neurorepair. However, the mechanisms by which APP exerts its actions remain to be elucidated. The available evidence suggests that APP interacts both intracellularly and extracellularly to regulate various signal transduction mechanisms. © 2014 The Authors.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | Alzheimer’s disease, amyloid precursor protein, growth factor, heparin, neurotrophic, receptor |
| Research Division: | Biomedical and Clinical Sciences |
| Research Group: | Neurosciences |
| Research Field: | Neurosciences not elsewhere classified |
| Objective Division: | Health |
| Objective Group: | Clinical health |
| Objective Field: | Clinical health not elsewhere classified |
| UTAS Author: | Dawkins, E (Dr Edgar Dawkins) |
| UTAS Author: | Small, DH (Professor David Small) |
| ID Code: | 92204 |
| Year Published: | 2014 |
| Web of Science® Times Cited: | 137 |
| Deposited By: | Menzies Institute for Medical Research |
| Deposited On: | 2014-06-10 |
| Last Modified: | 2017-11-06 |
| Downloads: | 268 View Download Statistics |
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