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Insights into the physiological function of the β-amyloid precursor protein: beyond Alzheimer's disease


Dawkins, E and Small, DH, Insights into the physiological function of the β-amyloid precursor protein: beyond Alzheimer's disease, Journal of Neurochemistry, 129, (5) pp. 756-769. ISSN 0022-3042 (2014) [Refereed Article]


Copyright Statement

Copyright 2014 The Authors-This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, (CC BY-NC-ND 2.0 AU) which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modi!cations or adaptations are made.

DOI: doi:10.1111/jnc.12675


The ╬▓-amyloid precursor protein (APP) has been extensively studied for its role as the precursor of the ╬▓-amyloid protein (A╬▓) of Alzheimer's disease. However, the normal function of APP remains largely unknown. This article reviews studies on the structure, expression and post-translational processing of APP, as well as studies on the effects of APP in vitro and in vivo. We conclude that the published data provide strong evidence that APP has a trophic function. APP is likely to be involved in neural stem cell development, neuronal survival, neurite outgrowth and neurorepair. However, the mechanisms by which APP exerts its actions remain to be elucidated. The available evidence suggests that APP interacts both intracellularly and extracellularly to regulate various signal transduction mechanisms. ┬ę 2014 The Authors.

Item Details

Item Type:Refereed Article
Keywords:Alzheimerĺs disease, amyloid precursor protein, growth factor, heparin, neurotrophic, receptor
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Neurosciences not elsewhere classified
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Dawkins, E (Dr Edgar Dawkins)
UTAS Author:Small, DH (Professor David Small)
ID Code:92204
Year Published:2014
Web of Science® Times Cited:160
Deposited By:Menzies Institute for Medical Research
Deposited On:2014-06-10
Last Modified:2017-11-06
Downloads:287 View Download Statistics

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