eCite Digital Repository

Delayed plastic responses to anodal tDCS in older adults


Fujiyama, H and Hyde, J and Hinder, MR and Kim, S-J and McCormack, GH and Vickers, JC and Summers, JJ, Delayed plastic responses to anodal tDCS in older adults, Frontiers in Aging Neuroscience, 6 Article 115. ISSN 1663-4365 (2014) [Refereed Article]


Copyright Statement

Licensed under Creative Commons Attribution 3.0 Unported (CC BY 3.0)

DOI: doi:10.3389/fnagi.2014.00115


Despite the abundance of research reporting the neurophysiological and behavioral effects of transcranial direct current stimulation (tDCS) in healthy young adults and clinical populations, the extent of potential neuroplastic changes induced by tDCS in healthy older adults is not well understood. The present study compared the extent and time course of anodal tDCS-induced plastic changes in primary motor cortex (M1) in young and older adults. Furthermore, as it has been suggested that neuroplasticity and associated learning depends on the brain-derived neurotrophic factor (BDNF) gene polymorphisms, we also assessed the impact of BDNF polymorphism on these effects. Corticospinal excitability was examined using transcranial magnetic stimulation before and following (0, 10, 20, 30 min) anodal tDCS (30 min, 1 mA) or sham in young and older adults. While the overall extent of increases in corticospinal excitability induced by anodal tDCS did not vary reliably between young and older adults, older adults exhibited a delayed response; the largest increase in corticospinal excitability occurred 30 min following stimulation for older adults, but immediately post-stimulation for the young group. BDNF genotype did not result in significant differences in the observed excitability increases for either age group. The present study suggests that tDCS-induced plastic changes are delayed as a result of healthy aging, but that the overall efficacy of the plasticity mechanism remains unaffected.

Item Details

Item Type:Refereed Article
Keywords:use of brain stimulation in older adults
Research Division:Health Sciences
Research Group:Sports science and exercise
Research Field:Motor control
Objective Division:Health
Objective Group:Other health
Objective Field:Other health not elsewhere classified
UTAS Author:Fujiyama, H (Dr Hakuei Fujiyama)
UTAS Author:Hyde, J (Ms Jane Hyde)
UTAS Author:Hinder, MR (Associate Professor Mark Hinder)
UTAS Author:McCormack, GH (Mr Graeme McCormack)
UTAS Author:Vickers, JC (Professor James Vickers)
UTAS Author:Summers, JJ (Professor Jeffery Summers)
ID Code:92202
Year Published:2014
Funding Support:Australian Research Council (DE120100729)
Web of Science® Times Cited:77
Deposited By:Psychology
Deposited On:2014-06-10
Last Modified:2017-11-05
Downloads:630 View Download Statistics

Repository Staff Only: item control page