File(s) under permanent embargo
MITF E318K's effect on melanoma risk independent of, but modified by, other risk factors
journal contribution
posted on 2023-05-18, 01:18 authored by Berwick, M, MacArthur, J, Orlow, I, Kanetsky, P, Begg, CB, Luo, L, Reiner, A, Sharma, A, Armstrong, BK, Kricker, A, Cust, AE, Marrett, LD, Gruber, SB, Anton- Culver, H, Zanetti, R, Rosso, S, Gallagher, RP, Dwyer, T, Alison VennAlison Venn, Busam, K, From, L, White, K, Thomas, NEA rare germline variant in the microphthalmia-associated transcription factor (MITF) gene, E318K, has been reported as associated with melanoma. We confirmed its independent association with melanoma [odds ratio (OR) 1.7, 95% confidence interval (CI) = 1.1, 2.7, P = 0.03]; adjusted for age, sex, center, age × sex interaction, pigmentation characteristics, family history of melanoma, and nevus density). In stratified analyses, carriage of MITF E318K was associated with melanoma more strongly in people with dark hair than fair hair (P for interaction, 0.03) and in those with no moles than some or many moles (P for interaction, <0.01). There was no evidence of interaction between MC1R 'red hair variants' and MITF E318K. Moreover, risk of melanoma among carriers with 'low risk' phenotypes was as great or greater than among those with 'at risk' phenotypes with few exceptions. © 2014 John Wiley & Sons A/S.
History
Publication title
Pigment Cell and Melanoma ResearchVolume
27Pagination
485-488ISSN
1755-1471Department/School
Menzies Institute for Medical ResearchPublisher
Wiley-Blackwell Publishing, Inc.Place of publication
United StatesRights statement
Copyright 2014 John WileyRepository Status
- Restricted