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Effect of vitamin D supplementation on antibiotic use: a randomized controlled trial

journal contribution
posted on 2023-05-18, 01:18 authored by Tran, B, Armstrong, BK, Ebeling, PR, English, DR, Kimlin, MG, Van Der Pols, JC, Alison VennAlison Venn, Gebski, V, Whiteman, DC, Webb, PM, Neale, RE
Background: Observational data suggested that supplementation with vitamin D could reduce risk of infection, but trial data are inconsistent. Objective: We aimed to examine the effect of oral vitamin D supplementation on antibiotic use. Design: We conducted a post hoc analysis of data from pilot D-Health, which is a randomized trial carried out in a general community setting between October 2010 and February 2012. A total of 644 Australian residents aged 60-84 y were randomly assigned to receive monthly doses of a placebo (n = 214) or 30,000 (n = 215) or 60,000 (n = 215) IU oral cholecalciferol for ≤12 mo. Antibiotics prescribed during the intervention period were ascertained by linkage with pharmacy records through the national health insurance scheme (Medicare Australia). Results: People who were randomly assigned 60,000 IU cholecalciferol had nonsignificant 28% lower risk of having antibiotics prescribed at least once than did people in the placebo group (RR: 0.72; 95% CI: 0.48, 1.07). In analyses stratified by age, in subjects aged ≥70 y, there was a significant reduction in antibiotic use in the high-dose vitamin D compared with placebo groups (RR: 0.53; 95% CI: 0.32, 0.90), whereas there was no effect in participants aged <70 y (RR: 1.07; 95% CI: 0.58, 1.97) (P-interaction = 0.1). Conclusion: Although this study was a post hoc analysis and statistically nonsignificant, this trial lends some support to the hypothesis that supplementation with 60,000 IU vitamin D/mo is associated with lower risk of infection, particularly in older adults. The trial was registered at the Australian New Zealand Clinical Trials Registry (anzctr.org.au) as ACTRN12609001063202. © 2014 American Society for Nutrition.

History

Publication title

American journal of clinical nutrition

Volume

99

Pagination

156-161

ISSN

0002-9165

Department/School

Menzies Institute for Medical Research

Publisher

Amer Soc Clinical Nutrition

Place of publication

9650 Rockville Pike, Subscriptions, Rm L-3300, Bethesda, USA, Md, 20814-3998

Rights statement

Copyright 2014 American Society for Nutrition

Repository Status

  • Restricted

Socio-economic Objectives

Preventive medicine

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