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Effect of vitamin D supplementation on antibiotic use: a randomized controlled trial


Tran, B and Armstrong, BK and Ebeling, PR and English, DR and Kimlin, MG and Van Der Pols, JC and Venn, A and Gebski, V and Whiteman, DC and Webb, PM and Neale, RE, Effect of vitamin D supplementation on antibiotic use: a randomized controlled trial, American journal of clinical nutrition, 99, (1) pp. 156-161. ISSN 0002-9165 (2014) [Refereed Article]

Copyright Statement

Copyright 2014 American Society for Nutrition

DOI: doi:10.3945/ajcn.113.063271


Background: Observational data suggested that supplementation with vitamin D could reduce risk of infection, but trial data are inconsistent. Objective: We aimed to examine the effect of oral vitamin D supplementation on antibiotic use. Design: We conducted a post hoc analysis of data from pilot D-Health, which is a randomized trial carried out in a general community setting between October 2010 and February 2012. A total of 644 Australian residents aged 60-84 y were randomly assigned to receive monthly doses of a placebo (n = 214) or 30,000 (n = 215) or 60,000 (n = 215) IU oral cholecalciferol for ≤12 mo. Antibiotics prescribed during the intervention period were ascertained by linkage with pharmacy records through the national health insurance scheme (Medicare Australia). Results: People who were randomly assigned 60,000 IU cholecalciferol had nonsignificant 28% lower risk of having antibiotics prescribed at least once than did people in the placebo group (RR: 0.72; 95% CI: 0.48, 1.07). In analyses stratified by age, in subjects aged ≥70 y, there was a significant reduction in antibiotic use in the high-dose vitamin D compared with placebo groups (RR: 0.53; 95% CI: 0.32, 0.90), whereas there was no effect in participants aged <70 y (RR: 1.07; 95% CI: 0.58, 1.97) (P-interaction = 0.1). Conclusion: Although this study was a post hoc analysis and statistically nonsignificant, this trial lends some support to the hypothesis that supplementation with 60,000 IU vitamin D/mo is associated with lower risk of infection, particularly in older adults. The trial was registered at the Australian New Zealand Clinical Trials Registry ( as ACTRN12609001063202. © 2014 American Society for Nutrition.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Public Health and Health Services
Research Field:Epidemiology
Objective Division:Health
Objective Group:Public Health (excl. Specific Population Health)
Objective Field:Preventive Medicine
Author:Venn, A (Professor Alison Venn)
ID Code:92013
Year Published:2014
Web of Science® Times Cited:18
Deposited By:Menzies Institute for Medical Research
Deposited On:2014-06-04
Last Modified:2017-11-03
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