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Hepatic encephalopathy associated with cancer or anticancer therapy
journal contribution
posted on 2023-05-18, 01:06 authored by Willson, KJ, Louise NottLouise Nott, Broadbridge, VT, Price, THepatic encephalopathy is an uncommon cause of neurologic deterioration associated with hyperammonemia, which results from hepatic dysfunction or altered ammonia metabolism. Often overlooked, hyperammonemia may occur via any of several pathophysiological processes, and in the setting of malignancy, it is a potentially reversible cause of confusion and coma. Hepatic dysfunction as a result of malignant infiltration, chemotherapeutic toxicities, targeted anticancer therapies, reactivation hepatitis, portosystemic shunting, and transarterial chemoembolization (TACE) is discussed, and an approach to etiological diagnosis and management is outlined.
History
Publication title
Gastrointestinal Cancer ResearchVolume
6Pagination
11-16ISSN
1934-7820Department/School
Menzies Institute for Medical ResearchPublisher
International Society of Gastrointestinal OncologyPlace of publication
United StatesRights statement
Copyright 2013 International Society of Gastrointestinal OncologyRepository Status
- Restricted