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Expression of Wnt signaling skeletal development genes in the cartilaginous fish, elephant shark (Callorhinchus milii)

Citation

D Souza, DG and Rana, K and Milley, KM and MacLean, HE and Zajac, JD and Bell, J and Brenner, S and Venkatesh, B and Richardson, SJ and Danks, JA, Expression of Wnt signaling skeletal development genes in the cartilaginous fish, elephant shark (Callorhinchus milii), General and Comparative Endocrinology, 193 pp. 1-9. ISSN 0016-6480 (2013) [Refereed Article]

Copyright Statement

Copyright 2013 Elsevier

DOI: doi:10.1016/j.ygcen.2013.06.021

Abstract

Jawed vertebrates (Gnasthostomes) are broadly separated into cartilaginous fishes (Chondricthyes) and bony vertebrates (Osteichthyes). Cartilaginous fishes are divided into chimaeras (e.g. ratfish, rabbit fish and elephant shark) and elasmobranchs (e.g. sharks, rays and skates). Both cartilaginous fish and bony vertebrates are believed to have a common armoured bony ancestor (Class Placodermi), however cartilaginous fish are believed to have lost bone. This study has identified and investigated genes involved in skeletal development in vertebrates, in the cartilaginous fish, elephant shark (Callorhinchus milii). Ctnnb1 (β-catenin), Sfrp (secreted frizzled protein) and a single Sost or Sostdc1 gene (sclerostin or sclerostin domain-containing protein 1) were identified in the elephant shark genome and found to be expressed in a number of tissues, including cartilage. β-catenin was also localized in several elephant shark tissues. The expression of these genes, which belong to the Wnt/β-catenin pathway, is required for normal bone formation in mammals. These findings in the cartilaginous skeleton of elephant shark support the hypothesis that the common ancestor of cartilaginous fishes and bony vertebrates had the potential for making bone.

Item Details

Item Type:Refereed Article
Keywords:bone, cartilage, elephant shark, sclerostin, secreted frizzled related protein, beta-catenin
Research Division:Agricultural and Veterinary Sciences
Research Group:Fisheries Sciences
Research Field:Fish Physiology and Genetics
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Biological Sciences
Author:Bell, J (Dr Justin Bell)
ID Code:91646
Year Published:2013
Web of Science® Times Cited:1
Deposited By:Sustainable Marine Research Collaboration
Deposited On:2014-05-23
Last Modified:2017-10-31
Downloads:0

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