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Aldose reductase gene polymorphisms and diabetic retinopathy susceptibility

Citation

Abhary, S and Burdon, KP and Laurie, KJ and Thorpe, S and Landers, J and Goold, L and Lake, S and Petrovsky, N and Craig, JE, Aldose reductase gene polymorphisms and diabetic retinopathy susceptibility, Diabetes Care, 33, (8) pp. 1834-1836. ISSN 0149-5992 (2010) [Refereed Article]


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Copyright Statement

Copyright 2010 The Authors-this article has been distributed under the terms of the Creative Commons Atttribution -NonCommercial-Noderivs 3.0 Australia (CC BY-NC-ND 3.0 AU)

Official URL: http://dx.doi.org/I 0.2337/dc09- !893

DOI: doi:10.2337/dc09-1893

Abstract

OBJECTIVE - Aldose reductase (ALR) is involved in diabetic microvascular damage via the polyol pathway. A recent meta-analysis found genetic variation in the ALR gene (AKR1B1) to be significantly associated with diabetic retinopathy (DR). We investigated the genetic association of AKR1B1 with DR. RESEARCH DESIGN AND METHODS - The study enrolled 909 individuals with diabetes. Participants were genotyped for an AKR1B1 (CA)n microsatellite and 14 tag single nucleotide polymorphisms, and ophthalmological assessment was performed. RESULTS - A total of 514 individuals were found to have DR. rs9640883 was significantly associated with DR (P = 0.0005). However, AKR1B1 variation was not independently associated with DR development after adjusting for relevant clinical parameters. rs9640883 was associated with duration of diabetes (P = 0.002). CONCLUSION - Many previous reports have failed to account for known risk factors for DR. The commonly reported association of AKR1B1 with DR may be due to an association of the gene with younger age at onset of diabetes.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Ophthalmology and Optometry
Research Field:Ophthalmology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Hearing, Vision, Speech and Their Disorders
Author:Burdon, KP (Associate Professor Kathryn Burdon)
ID Code:91367
Year Published:2010
Web of Science® Times Cited:13
Deposited By:Menzies Institute for Medical Research
Deposited On:2014-05-15
Last Modified:2014-06-19
Downloads:192 View Download Statistics

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