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Pregnane steroids and short-term neural plasticity

Citation

Saalmann, YB and Calford, MB, Pregnane steroids and short-term neural plasticity, Neuroactive Steroids in Brain Function, Behavior and Neuropsychiatric Disorders: Novel Strategies for Research and Treatment, Springer Netherlands, MS Ritsner & A Weizman (ed), Netherlands, pp. 187-200. ISBN 978-1-4020-6853-9 (2008) [Research Book Chapter]

DOI: doi:10.1007/978-1-4020-6854-6_9

Abstract

Gamma-aminobutyric acid (GABA) is the major inhibitory transmitter in the brain, and its fast effects are mediated by the GABA-A receptor. It is well known, from pharmacological manipulations, that many exogenous agents alter the efficacy of GABA-A receptors. For example, benzodiazepines increase the effect of GABA and some β-carbolines reduce the effect of GABA at these receptors. Increasing the strength of neuronal inhibition can prevent seizures, reduce anxiety and be neuroprotective. There are also endogenous mechanisms that increase efficacy. For example, more GABA-A receptors can be synthesized and inserted into synapses, but this requires up to 1 h or more. On a shorter timescale, GABAergic inhibition can be potentiated by steroids, e.g., allopregnanolone, synthesized de novo in neural tissue or derived from peripheral endocrine organs. The widespread distribution of these neuroactive steroids across the brain suggests an extensive role in short-term neural plasticity. © 2008 Springer Netherlands.

Item Details

Item Type:Research Book Chapter
Keywords:Allopregnanolone; allotetrahydrodeoxycorticosterone; GABA; gain control; homeostasis
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Neurology and Neuromuscular Diseases
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Nervous System and Disorders
Author:Calford, MB (Professor Mike Calford)
ID Code:91315
Year Published:2008
Deposited By:Research Division
Deposited On:2014-05-13
Last Modified:2014-05-13
Downloads:0

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