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Activity-dependent maintenance and growth of dendrites in adult cortex

Citation

Tailby, C and Wright, LL and Metha, AB and Calford, MB, Activity-dependent maintenance and growth of dendrites in adult cortex, Proceedings of the National Academy of Sciences of the United States of America, 102, (12) pp. 4631-4636. ISSN 0027-8424 (2005) [Refereed Article]

DOI: doi:10.1073/pnas.0402747102

Abstract

Whereas it is widely accepted that the adult cortex is capable of a remarkable degree of functional plasticity, demonstrations of accompanying structural changes have been limited. We examined the basal dendritic field morphology of dye-filled neurons in layers III and IV of the mature barrel cortex after vibrissal-deafferentation in adult rats. Eight weeks later, the tendency for these neurons to orient their dendritic arbors toward the center of their home barrel was found to be disrupted by the resultant reduced activity of thalamocortical innervation. Measures of spine density and total dendritic length were normal, indicating that the loss of dendritic bias was accompanied by growth of dendrites directed away from the barrel center. This finding suggests that in the mature cortex, the apparently static structural attributes of the normal adult cortex depend on maintenance of patterns of afferent activity; with the corollary that changes in these patterns can induce structural plasticity. © 2005 by The National Academy of Sciences of the USA.

Item Details

Item Type:Refereed Article
Keywords:Barrel field; Plasticity; Pyramidal cell; Spines; Vibrissae; adolescent; animal tissue; article; brain cortex; brain maturation; cell structure; controlled study; dendrite; dendritic spine; female; nerve cell plasticity; nonhuman
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Neurology and Neuromuscular Diseases
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Nervous System and Disorders
Author:Calford, MB (Professor Mike Calford)
ID Code:91303
Year Published:2005
Web of Science® Times Cited:67
Deposited By:Research Division
Deposited On:2014-05-13
Last Modified:2014-05-13
Downloads:0

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