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Multi-elemental analysis of brain tissue from healthy Wistar rats using sector field inductively coupled plasma mass spectrometry

Citation

Paul, MC and Parsons, CH and Calford, MB and Von Nagy-Felsobuki, EI, Multi-elemental analysis of brain tissue from healthy Wistar rats using sector field inductively coupled plasma mass spectrometry, Spectrochimica Acta - Part B Atomic Spectroscopy, 59, (9) pp. 1485-1490. ISSN 0584-8547 (2004) [Refereed Article]

DOI: doi:10.1016/j.sab.2004.06.008

Abstract

The normal distribution of a range of elements in the brain tissue of healthy Wistar rats was established using sector field inductively coupled plasma mass spectrometry. A protocol was developed to determine concentrations of Ag, Cd, Hg, Pb, Bi, U, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, As and Se in specific brain regions. The concentrations of these elements were determined in the range of 2±1 (e.g. Cr in diencephalon) to 7558±450 ng ml-1 (e.g. Fe in olfactory bulb). The detection limits of the sixteen elements ranged between 5 and 300 pg ml-1, with U yielding the lowest and Fe the highest value. The validity of the protocol was assessed by the analysis of SRM 1577B Bovine Liver and brain tissue spike recoveries. A principal component analysis was used to reveal elemental patterns of the brain regions. © 2004 Elsevier B.V. All rights reserved.

Item Details

Item Type:Refereed Article
Keywords:Brain tissue; Multi-elemental analysis; Sector field ICP-MS; Wistar rat; Brain; Environmental impact; Inductively coupled plasma; Iron; Neurology; Silver; Tissue; Trace elements; Brain tissue; Multi-elemental analysis; Wistar rats
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Neurology and Neuromuscular Diseases
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Nervous System and Disorders
Author:Calford, MB (Professor Mike Calford)
ID Code:91298
Year Published:2004
Web of Science® Times Cited:17
Deposited By:Research Division
Deposited On:2014-05-13
Last Modified:2014-05-13
Downloads:0

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