Cortical plasticity revealed by circumscribed retinal lesions or artificial scotomas
Dreher, B and Burke, W and Calford, MB, Cortical plasticity revealed by circumscribed retinal lesions or artificial scotomas, Progress in Brain Research, 134 pp. 217-246. ISSN 0079-6123 (2001) [Refereed Article]
We review the work of others in which the effects of circumscribed, topographically corresponding binocular retinal lesions on the topographic organization of the visual cortex revealed that there is a substantial degree of topographical plasticity in the primary visual cortices of adult cats and macaque monkeys. Despite the evidence indicating that the reorganization of the topographic map in primary visual cortices of adult cats and macaques related to the input from one eye could be suppressed for a long time by inputs related to the other eye, we observed a substantial degree of topographical plasticity in the primary visual cortices of adult cats in which we have made circumscribed monocular retinal lesions. Overall, in both binocularly and monocularly lesioned adult animals, most cells recorded in the cortical projection zone of the retinal lesion (LPZ), several hours, several weeks or several months after placement of the lesions exhibited 'ectopic' excitatory visual receptive fields (RFs) which were displaced to the normal retina in the immediate vicinity of the lesion. The presence of ectopic RFs in cells recorded in the cortical LPZ, combined with the presence of normal cortical representation of the part of the retina in the vicinity of the lesion, indicate a clear expansion of the cortical representation of the part of the retina surrounding the lesion. When stimulated via the ectopic RFs, cortical cells exhibited normal orientation tuning and in the case of animals with monocular lesions, the orientation tuning of binocular cells when stimulated via ectopic RFs appeared to be very similar to that when the cells were stimulated via the RFs in the normal, unlesioned eye. In both binocularly and monocularly lesioned animals, the responses evoked by optimal visual stimuli from the ectopic RFs were substantially weaker than those evoked from their normal counterparts. Similarly, upper velocity limits were significantly lower when visual stimuli were presented via the ectopic RFs. In contrast to cats in which the retinal lesions were made in adulthood, in cats lesioned monocularly in adolescence (8-11 weeks postnatal), both the peak discharge rates and upper velocity limits of responses to photic stimuli presented via the ectopic RFs were very similar to those to stimuli presented via the normal eye. The intracortical mechanism(s) underlying the long-term cortical plasticity revealed by retinal lesions are likely to be closely linked to the mechanism(s) underlying the short-term reversible enlargement of cortical receptive fields observed with artificial scotomas. Furthermore, a similar putative intracortical mechanism(s) appears to underlie psychophysical phenomena observed in studies of retinal scotomas in humans. Overall, the research reviewed here strongly challenges the view that receptive fields of neurons in mammalian visual cortices are 'hard-wired'.