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Neuroplasticity and psychiatry


Gynther, BD and Calford, MB and Sah, P, Neuroplasticity and psychiatry, Australian and New Zealand Journal of Psychiatry, 32, (1) pp. 119-128. ISSN 0004-8674 (1998) [Refereed Article]

DOI: doi:10.1046/j.1440-1614.1998.00381.x


Objective: There is increasing concern that the course of psychiatric disorders may be affected by parameters such as the duration and intensity of symptoms of initial episodes of illness. As this indicates that abnormal function produces long-term changes within the brain, a review of the neuroscience literature regarding neuroplasticity is warranted. Method: This article is a selective review, focusing in particular on results obtained from physiological experiments assessing plasticity within the mammalian neocortex. The possible relevance of results to psychiatry is discussed. Results: While the most dramatic examples of neuroplasticity occur during a critical period of neural development, neuroplasticity can also occur in adult neocortex. Neuroplasticity appears to be activity-dependent: synaptic pathways that are intensively used may become strengthened, and conversely, there may be depression of transmission in infrequently used pathways. Conclusions: Results from neurophysiological experiments lend support to the clinical observation that the intensity and duration of a psychiatric disorder may adversely alter its long-term course. Rapid aggressive treatment may prevent this from occurring. While pharmacotherapy may reduce the duration and severity of symptoms, it may also have an independent, as yet unknown, effect on neuroplasticity.

Item Details

Item Type:Refereed Article
Keywords:Long-term potentiation; Neuroplasticity; Psychiatry; Sensory cortex; disease duration; disease severity; human; mammal; mental disease; neocortex; nerve cell plasticity; psychiatry; review; sensory cortex; Adult; Brain; Humans
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Neurology and neuromuscular diseases
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Calford, MB (Professor Mike Calford)
ID Code:91286
Year Published:1998
Web of Science® Times Cited:1
Deposited By:Research Division
Deposited On:2014-05-13
Last Modified:2014-05-13

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