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Immediate and chronic changes in responses of somatosensory cortex in adult flying-fox after digit amputation

Citation

Calford, MB and Tweedale, R, Immediate and chronic changes in responses of somatosensory cortex in adult flying-fox after digit amputation, Nature, 332, (6163) pp. 446-448. ISSN 0028-0836 (1988) [Refereed Article]

DOI: doi:10.1038/332446a0

Abstract

The somatosensory cortex of adult mammals has been shown to have a capacity to reorganize when inputs are removed by cutting afferent nerves or amputating a part of the body. The area of cortex that would normally respond to stimulation of the missing input can become responsive to inputs from other parts of the body surface. Although a few animals have been studied with repeat recording, no attempt has been made to follow the time-course of changes at cortical loci and the immediate effects of a small amputation have not been reported. We have followed the changes in response in the primary somatosensory cortex in the flying-fox following amputation of the single-exposed digit on the forelimb. Immediately after amputation, neurons in the area of cortex receiving inputs from the missing digit were not silent but responded to stimulation of adjoining regions of the digit, hand, arm and wing. In the week following amputation, the enlarged receptive fields shrank until they covered only the skin around the amputation wound. The immediate response is interpreted as a removal of inhibition and the subsequent shrinking of the field may be due to re-establishment of the inhibitory balance in the affected cortex and its inputs.

Item Details

Item Type:Refereed Article
Keywords:animal experiment; finger amputation; mammal; nonhuman; receptive field; somatosensory cortex; Amputation; Animal; Chiroptera; Evoked Potentials, Somatosensory; Somatosensory Cortex; Support, Non-U.S. Gov't; Wing
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Neurology and Neuromuscular Diseases
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Nervous System and Disorders
Author:Calford, MB (Professor Mike Calford)
ID Code:91259
Year Published:1988
Web of Science® Times Cited:286
Deposited By:Research Division
Deposited On:2014-05-13
Last Modified:2014-05-13
Downloads:0

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