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Reliability of heart rate variability in patients with Type 2 diabetes mellitus

Citation

Sacre, JW and Jellis, CL and Marwick, TH and Coombes, JS, Reliability of heart rate variability in patients with Type 2 diabetes mellitus, Diabetic Medicine, 29, (7) pp. e33-e40. ISSN 0742-3071 (2012) [Refereed Article]

Copyright Statement

Copyright 2011 The Authors. Diabetic Medicine Copyright 2011 Diabetes UK

DOI: doi:10.1111/j.1464-5491.2011.03557.x

Abstract

Aims  Heart rate variability may be used to assess diabetic cardiac autonomic neuropathy. The aim of the present study was to determine the reliability of standard short-term clinical measurements of heart rate variability in patients with Type 2 diabetes.

Methods  In 24 patients with Type 2 diabetes (11 male, age 61 9 years), parameters of heart rate variability in the time domain (standard deviation of RR intervals, coefficient of variation of RR intervals and root mean square of successive RR interval differences) and frequency domain (very low frequency, low frequency, high frequency and total spectral power) were derived from a 5-min electrocardiograph recorded during two laboratory visits separated by 16 8 days. Absolute and relative reliability were assessed by 95% limits of random variation and the intraclass correlation coefficient, respectively. Categorical agreement of classifications of heart rate variability and sample size estimates for clinical trials were calculated.

Results  Despite no significant difference in mean heart rate variability between tests, 95% limits of random variation indicated that repeated measurements were between 58% higher/37% lower (most reliable parameter; coefficient of variation of RR intervals) and 443% higher/82% lower (least reliable parameter; very low frequency power) than the first measure. The intraclass correlation coefficient ranged from 0.58 to 0.90 and sample size requirements from 20 to 93 patients per group. Agreement of categories of heart rate variability ranged from 79 to 96%.

Conclusions  Short-term clinical measurements of heart rate variability in patients with Type 2 diabetes are characterized by poor absolute reliability, but substantial to good relative reliability, suggesting greater clinical utility in diagnosis than in sequential follow-up.

Item Details

Item Type:Refereed Article
Keywords:diabetic autonomic neuropathy, heart rate variability, reproducibility of results, sample size, Type 2 diabetes mellitus
Research Division:Medical and Health Sciences
Research Group:Cardiorespiratory Medicine and Haematology
Research Field:Cardiology (incl. Cardiovascular Diseases)
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Cardiovascular System and Diseases
Author:Marwick, TH (Professor Tom Marwick)
ID Code:91213
Year Published:2012
Web of Science® Times Cited:10
Deposited By:Menzies Institute for Medical Research
Deposited On:2014-05-12
Last Modified:2014-06-02
Downloads:0

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