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The genetics of central corneal thickness
Citation
Dimasi, DP and Burdon, KP and Craig, JE, The genetics of central corneal thickness, British Journal of Ophthalmology, 94, (8) pp. 971-976. ISSN 0007-1161 (2010) [Substantial Review]
Copyright Statement
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DOI: doi:10.1136/bjo.2009.162735
Abstract
Evidence in the recent literature has highlighted the importance of central corneal thickness (CCT) in relation to several ocular and non-ocular conditions. Most notably, thinner CCT has been identified as a risk factor for open-angle glaucoma. Despite having an extensive knowledge of the structure and function of the cornea, little is known about the pathways that determine CCT. There are data to suggest however that CCT has a strong genetic component. Heritability studies conducted in twins and family pedigrees indicate that CCT is one of the most highly heritable human traits, whereas data from a diverse range of ethnic groups show clear ethnic-related differences in CCT. Extreme CCT measurements have also been associated with rare genetic diseases. Although there is strong evidence supporting a genetic component to normal CCT variation, to date, no genes have been identified. This review investigates the current literature surrounding this topic and explores the significance of understanding the genetics of CCT and how this might benefit the field of open-angle glaucoma treatment and research.
Item Details
Item Type: | Substantial Review |
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Research Division: | Biomedical and Clinical Sciences |
Research Group: | Ophthalmology and optometry |
Research Field: | Ophthalmology |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | Burdon, KP (Professor Kathryn Burdon) |
ID Code: | 91100 |
Year Published: | 2010 |
Web of Science® Times Cited: | 68 |
Deposited By: | Menzies Institute for Medical Research |
Deposited On: | 2014-05-07 |
Last Modified: | 2019-08-28 |
Downloads: | 0 |
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