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Diabetic retinopathy is associated with elevated serum asymmetric and symmetric dimethylarginines

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posted on 2023-05-18, 00:21 authored by Abhary, S, Kasmeridis, N, Kathryn BurdonKathryn Burdon, Kuot, A, Whiting, MJ, Wai, PY, Petrovsky, N, Craig, JE
OBJECTIVE - Asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA), and L-arginine directly influence nitric oxide production. Our objective was to test whether serum ADMA, SDMA, or L-arginine levels correlate with diabetic retinopathy subtype or severity. RESEARCH DESIGN AND METHODS - A total of 162 subjects with type 1 diabetes and 343 with type 2 diabetes, of whom 329 subjects had no diabetic retinopathy, 27 had nonproliferative diabetic retinopathy (NPDR), 101 had proliferative diabetic retinopathy (PDR), and 107 had clinically significant macular edema (CSME), were recruited. Blinding diabetic retinopathy was defined as severe NPDR, PDR, or CSME. Serum ADMA, SDMA, and L-arginine concentrations were determined by mass spectroscopy. RESULTS - In multivariate analysis, blinding diabetic retinopathy, PDR, and nephropathy were associated with significantly increased serum levels of ADMA (P < 0.001), SDMA (P < 0.001), and L-arginine (P = 0.001). Elevated ADMA (P < 0.001) and SDMA (P < 0.001) were also significantly associated with CSME. CONCLUSIONS - Severe forms of diabetic retinopathy are associated with elevated serum ADMA, SDMA, and L-arginine. Further investigation is required to determine whether these findings are of clinical relevance.

History

Publication title

Diabetes Care

Volume

32

Issue

11

Pagination

2084-2086

ISSN

0149-5992

Department/School

Menzies Institute for Medical Research

Publisher

Amer Diabetes Assoc

Place of publication

1701 N Beauregard St, Alexandria, USA, Va, 22311-1717

Rights statement

Copyright 2009 The Authors-this article is distributed under the Creative Commons (CC BY-NC-ND 3.0 AU) license.

Repository Status

  • Open

Socio-economic Objectives

Clinical health not elsewhere classified

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