91096 Journal Article_Abhary.pdf (1.08 MB)
Diabetic retinopathy is associated with elevated serum asymmetric and symmetric dimethylarginines
journal contribution
posted on 2023-05-18, 00:21 authored by Abhary, S, Kasmeridis, N, Kathryn BurdonKathryn Burdon, Kuot, A, Whiting, MJ, Wai, PY, Petrovsky, N, Craig, JEOBJECTIVE - Asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA), and L-arginine directly influence nitric oxide production. Our objective was to test whether serum ADMA, SDMA, or L-arginine levels correlate with diabetic retinopathy subtype or severity. RESEARCH DESIGN AND METHODS - A total of 162 subjects with type 1 diabetes and 343 with type 2 diabetes, of whom 329 subjects had no diabetic retinopathy, 27 had nonproliferative diabetic retinopathy (NPDR), 101 had proliferative diabetic retinopathy (PDR), and 107 had clinically significant macular edema (CSME), were recruited. Blinding diabetic retinopathy was defined as severe NPDR, PDR, or CSME. Serum ADMA, SDMA, and L-arginine concentrations were determined by mass spectroscopy. RESULTS - In multivariate analysis, blinding diabetic retinopathy, PDR, and nephropathy were associated with significantly increased serum levels of ADMA (P < 0.001), SDMA (P < 0.001), and L-arginine (P = 0.001). Elevated ADMA (P < 0.001) and SDMA (P < 0.001) were also significantly associated with CSME. CONCLUSIONS - Severe forms of diabetic retinopathy are associated with elevated serum ADMA, SDMA, and L-arginine. Further investigation is required to determine whether these findings are of clinical relevance.
History
Publication title
Diabetes CareVolume
32Issue
11Pagination
2084-2086ISSN
0149-5992Department/School
Menzies Institute for Medical ResearchPublisher
Amer Diabetes AssocPlace of publication
1701 N Beauregard St, Alexandria, USA, Va, 22311-1717Rights statement
Copyright 2009 The Authors-this article is distributed under the Creative Commons (CC BY-NC-ND 3.0 AU) license.Repository Status
- Open