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Diabetic retinopathy is associated with elevated serum asymmetric and symmetric dimethylarginines

Citation

Abhary, S and Kasmeridis, N and Burdon, KP and Kuot, A and Whiting, MJ and Wai, PY and Petrovsky, N and Craig, JE, Diabetic retinopathy is associated with elevated serum asymmetric and symmetric dimethylarginines, Diabetes Care, 32, (11) pp. 2084-2086. ISSN 0149-5992 (2009) [Refereed Article]


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Copyright Statement

Copyright 2009 The Authors-this article is distributed under the Creative Commons (CC BY-NC-ND 3.0 AU) license.

DOI: doi:10.2337/dc09-0816

Abstract

OBJECTIVE - Asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA), and L-arginine directly influence nitric oxide production. Our objective was to test whether serum ADMA, SDMA, or L-arginine levels correlate with diabetic retinopathy subtype or severity. RESEARCH DESIGN AND METHODS - A total of 162 subjects with type 1 diabetes and 343 with type 2 diabetes, of whom 329 subjects had no diabetic retinopathy, 27 had nonproliferative diabetic retinopathy (NPDR), 101 had proliferative diabetic retinopathy (PDR), and 107 had clinically significant macular edema (CSME), were recruited. Blinding diabetic retinopathy was defined as severe NPDR, PDR, or CSME. Serum ADMA, SDMA, and L-arginine concentrations were determined by mass spectroscopy. RESULTS - In multivariate analysis, blinding diabetic retinopathy, PDR, and nephropathy were associated with significantly increased serum levels of ADMA (P < 0.001), SDMA (P < 0.001), and L-arginine (P = 0.001). Elevated ADMA (P < 0.001) and SDMA (P < 0.001) were also significantly associated with CSME. CONCLUSIONS - Severe forms of diabetic retinopathy are associated with elevated serum ADMA, SDMA, and L-arginine. Further investigation is required to determine whether these findings are of clinical relevance.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Ophthalmology and Optometry
Research Field:Ophthalmology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Hearing, Vision, Speech and Their Disorders
Author:Burdon, KP (Associate Professor Kathryn Burdon)
ID Code:91096
Year Published:2009
Web of Science® Times Cited:17
Deposited By:Menzies Institute for Medical Research
Deposited On:2014-05-07
Last Modified:2014-12-15
Downloads:275 View Download Statistics

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