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Trypanocidal activity of Brazilian plants against epimastigote forms from Y and Bolivia strains of Trypanosoma cruzi

Citation

Alves, RT and Regasini, LO and Funari, CS and Young, MCM and Rimoldi, A and da Silva Bolzani, V and Silva, DHS and de Albuquerque, S and da Rosa, JA, Trypanocidal activity of Brazilian plants against epimastigote forms from Y and Bolivia strains of Trypanosoma cruzi, Revista Brasileira de Farmacognosia, 22, (3) pp. 528-533. ISSN 0102-695X (2012) [Refereed Article]


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Copyright Statement

Copyright 2012 Sociedade Brasileira de Farmacognosia Licenced under Creative Commons Attribution-NonCommercial 3.0 Unported (CC BY-NC 3.0) http://creativecommons.org/licenses/by-nc/3.0/

DOI: doi:10.1590/S0102-695X2012005000014

Abstract

Chagas disease is one of the main public health problems in Latin America. Since the available treatments for this disease are not effective in providing cure, the screening of potential antiprotozoal agents is essential, mainly of those obtained from natural sources. This study aimed to provide an evaluation of the trypanocidal activity of 92 ethanol extracts from species belonging to the families Annonaceae, Apiaceae, Cucurbitaceae, Lamiaceae, Lauraceae, Moraceae, Nyctaginaceae, and Verbenaceae against the Y and Bolivia strains of Trypanosoma cruzi. Additionally, cytotoxic activity on LLCMK2 fi broblasts was evaluated. Both the trypanocidal activity and cytotoxicity were evaluated using the MTT method, in the following concentrations: 500, 350, 250, and 100 μg/mL. Benznidazole was used for positive control. The best results among the 92 samples evaluated were obtained with ethanol extracts of Ocotea paranapiacabensis (Am93) and Aegiphila lhotzkiana (Am160). Am93 showed trypanocidal activity against epimastigote forms of the Bolivia strain and was moderately toxic to LLCMK2 cells, its Selectivity Index (SI) being 14.56, while Am160 showed moderate trypanocidal activity against the Bolivia strain and moderate toxicicity, its SI being equal to 1.15. The screening of Brazilian plants has indicated the potential effect of ethanol extracts obtained from Ocotea paranapiacabensis and Aegiphila lhotzkiana against Chagas disease.

Item Details

Item Type:Refereed Article
Keywords:biodiversity, Chagas, cytotoxicity, disease, strains, trypanocidal activity, Trypanosoma cruzi
Research Division:Chemical Sciences
Research Group:Analytical Chemistry
Research Field:Separation Science
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Chemical Sciences
Author:Funari, CS (Dr Cristiano Funari)
ID Code:91088
Year Published:2012
Web of Science® Times Cited:4
Deposited By:Austn Centre for Research in Separation Science
Deposited On:2014-05-07
Last Modified:2014-08-12
Downloads:216 View Download Statistics

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