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Trypanocidal activity of Brazilian plants against epimastigote forms from Y and Bolivia strains of Trypanosoma cruzi
Citation
Alves, RT and Regasini, LO and Funari, CS and Young, MCM and Rimoldi, A and da Silva Bolzani, V and Silva, DHS and de Albuquerque, S and da Rosa, JA, Trypanocidal activity of Brazilian plants against epimastigote forms from Y and Bolivia strains of Trypanosoma cruzi, Revista Brasileira de Farmacognosia, 22, (3) pp. 528-533. ISSN 0102-695X (2012) [Refereed Article]
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Copyright Statement
Copyright 2012 Sociedade Brasileira de Farmacognosia Licenced under Creative Commons Attribution-NonCommercial 3.0 Unported (CC BY-NC 3.0) http://creativecommons.org/licenses/by-nc/3.0/
DOI: doi:10.1590/S0102-695X2012005000014
Abstract
Chagas disease is one of the main public health problems in Latin America.
Since the available treatments for this disease are not effective in providing cure, the
screening of potential antiprotozoal agents is essential, mainly of those obtained from
natural sources. This study aimed to provide an evaluation of the trypanocidal activity
of 92 ethanol extracts from species belonging to the families Annonaceae, Apiaceae,
Cucurbitaceae, Lamiaceae, Lauraceae, Moraceae, Nyctaginaceae, and Verbenaceae
against the Y and Bolivia strains of Trypanosoma cruzi. Additionally, cytotoxic activity
on LLCMK2 fi broblasts was evaluated. Both the trypanocidal activity and cytotoxicity
were evaluated using the MTT method, in the following concentrations: 500, 350, 250,
and 100 μg/mL. Benznidazole was used for positive control. The best results among the
92 samples evaluated were obtained with ethanol extracts of Ocotea paranapiacabensis
(Am93) and Aegiphila lhotzkiana (Am160). Am93 showed trypanocidal activity against
epimastigote forms of the Bolivia strain and was moderately toxic to LLCMK2 cells, its
Selectivity Index (SI) being 14.56, while Am160 showed moderate trypanocidal activity
against the Bolivia strain and moderate toxicicity, its SI being equal to 1.15. The screening
of Brazilian plants has indicated the potential effect of ethanol extracts obtained from
Ocotea paranapiacabensis and Aegiphila lhotzkiana against Chagas disease.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | biodiversity, Chagas, cytotoxicity, disease, strains, trypanocidal activity, Trypanosoma cruzi |
| Research Division: | Chemical Sciences |
| Research Group: | Analytical Chemistry |
| Research Field: | Separation Science |
| Objective Division: | Expanding Knowledge |
| Objective Group: | Expanding Knowledge |
| Objective Field: | Expanding Knowledge in the Chemical Sciences |
| Author: | Funari, CS (Dr Cristiano Funari) |
| ID Code: | 91088 |
| Year Published: | 2012 |
| Web of Science® Times Cited: | 7 |
| Deposited By: | Austn Centre for Research in Separation Science |
| Deposited On: | 2014-05-07 |
| Last Modified: | 2014-08-12 |
| Downloads: | 248 View Download Statistics |
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