eCite Digital Repository

Chemical and antifungal investigations of six Lippia species (Verbenaceae) from Brazil

Citation

Funari, CS and Gullo, FP and Napolitano, A and Carneiro, RL and Mendes-Giannini, MJS and Fusco-Almeida, AM and Piacente, S and Pizza, C and Silva, DHS, Chemical and antifungal investigations of six Lippia species (Verbenaceae) from Brazil, Food Chemistry, 135, (3) pp. 2086-2094. ISSN 0308-8146 (2012) [Refereed Article]

Copyright Statement

Copyright 2012 Elsevier Ltd.

DOI: doi:10.1016/j.foodchem.2012.06.077

Abstract

The Lippia genus is used in ethnobotany as food, beverages, seasoning and antiseptic remedies, among others. The chemical compositions of fifteen extracts of six Lippia species were investigated comparatively by HPLC–PDA. To avoid data replication of previous works on this genus, Lippia lupulina Cham. root ethanol extract was selected for isolation procedures based on Principal Component Analyses (PCA) of such data. Seven compounds previously unreported in this genus were isolated from this extract (a triterpene, two furanonaphtoquinones, a furanochromone, an isoflavone, a stilbene and an iridoid). The activities of extracts, fractions and pure compounds towards Candida albicans, Candida krusei, Candida parapsilosis and Cryptococcus neoformans were investigated. Two fractions from the extract of Lippia salviaefolia leaves showed marked inhibition of fungal growth, in addition to verbascoside and asebogenin, which showed MICs lower than 15.6 μg/ml and may be promising leads for the development of new antifungal agents, especially against C. neoformans.

Item Details

Item Type:Refereed Article
Keywords:Verbenaceae, Lippia spp, dereplication, antifungal, Candida spp, Cryptococcus neoformans
Research Division:Chemical Sciences
Research Group:Analytical Chemistry
Research Field:Separation Science
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Chemical Sciences
Author:Funari, CS (Dr Cristiano Funari)
ID Code:91085
Year Published:2012
Web of Science® Times Cited:16
Deposited By:Austn Centre for Research in Separation Science
Deposited On:2014-05-07
Last Modified:2014-06-06
Downloads:0

Repository Staff Only: item control page