Epoxide hydrolase is involved in metabolism of vasoactive and anti-inflammatory epoxyeicosatrienoic acids to their corresponding diols. Consequently, epoxide hydrolase 2 (EPHX2) is a candidate cardiovascular disease (CVD) gene. We investigated EPHX2 for association with subclinical CVD in European American (EA) and African American (AA) families from the Diabetes Heart Study. The R287Q polymorphism was associated with carotid artery calcified plaque (CarCP) in EAs. Other EPHX2 polymorphisms were associated with coronary artery calcified plaque (CorCP), CarCP or carotid artery intima-media thickness (IMT). Polymorphism rs7837347 was associated with all traits in the AAs (p=0.003, 0.001 and 0.017, respectively). Polymorphism rs7003694 displayed association with IMT (p=0.017) and, along with rs747276, a trend towards association with CorCP in diabetic EAs (p=0.05 7 and 0.080, respectively). These results provide additional evidence that EPHX2 contributes to the risk of subclinical CVD, although the true trait defining polymorphisms may not be identified and the effect size could be small.

Item Type:	Refereed Article
Keywords:	Calcified plaque; Cardiovascular disease; Gene polymorphisms; Type 2 diabetes
Research Division:	Biological Sciences
Research Group:	Genetics
Research Field:	Quantitative Genetics (incl. Disease and Trait Mapping Genetics)
Objective Division:	Health
Objective Group:	Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:	Diabetes
Author:	Burdon, KP (Associate Professor Kathryn Burdon)
ID Code:	91061
Year Published:	2008
Web of Science® Times Cited:	39
Deposited By:	Menzies Institute for Medical Research
Deposited On:	2014-05-06
Last Modified:	2014-06-24
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