eCite Digital Repository
Genetic analysis of the soluble epoxide hydrolase gene, EPHX2, in subclinical cardiovascular disease in the Diabetes Heart Study
Citation
Burdon, KP and Lehtinen, AB and Langefeld, CD and Carr, JJ and Rich, SS and Freedman, BI and Herrington, D and Bowden, DW, Genetic analysis of the soluble epoxide hydrolase gene, EPHX2, in subclinical cardiovascular disease in the Diabetes Heart Study, Diabetes and Vascular Disease Research, 5, (2) pp. 128-134. ISSN 1479-1641 (2008) [Refereed Article]
Copyright Statement
Copyright 2008 SAGE
DOI: doi:10.3132/dvdr.2008.021
Abstract
Epoxide hydrolase is involved in metabolism of vasoactive and anti-inflammatory epoxyeicosatrienoic acids to their corresponding diols. Consequently, epoxide hydrolase 2 (EPHX2) is a candidate cardiovascular disease (CVD) gene. We investigated EPHX2 for association with subclinical CVD in European American (EA) and African American (AA) families from the Diabetes Heart Study. The R287Q polymorphism was associated with carotid artery calcified plaque (CarCP) in EAs. Other EPHX2 polymorphisms were associated with coronary artery calcified plaque (CorCP), CarCP or carotid artery intima-media thickness (IMT). Polymorphism rs7837347 was associated with all traits in the AAs (p=0.003, 0.001 and 0.017, respectively). Polymorphism rs7003694 displayed association with IMT (p=0.017) and, along with rs747276, a trend towards association with CorCP in diabetic EAs (p=0.05 7 and 0.080, respectively). These results provide additional evidence that EPHX2 contributes to the risk of subclinical CVD, although the true trait defining polymorphisms may not be identified and the effect size could be small.
Item Details
Item Type: | Refereed Article |
---|---|
Keywords: | Calcified plaque; Cardiovascular disease; Gene polymorphisms; Type 2 diabetes |
Research Division: | Biological Sciences |
Research Group: | Genetics |
Research Field: | Gene mapping |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | Burdon, KP (Professor Kathryn Burdon) |
ID Code: | 91061 |
Year Published: | 2008 |
Web of Science® Times Cited: | 49 |
Deposited By: | Menzies Institute for Medical Research |
Deposited On: | 2014-05-06 |
Last Modified: | 2014-06-24 |
Downloads: | 0 |
Repository Staff Only: item control page