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Placental and embryonic tissues exhibit aromatase activity in the viviparous lizard Niveoscincus metallicus

Citation

Parsley, LM and Wapstra, E and Jones, SM, Placental and embryonic tissues exhibit aromatase activity in the viviparous lizard Niveoscincus metallicus, General and Comparative Endocrinology, 200 pp. 61-66. ISSN 0016-6480 (2014) [Refereed Article]

Copyright Statement

Copyright 2014 Elsevier Inc.

DOI: doi:10.1016/j.ygcen.2014.02.020

Abstract

Aromatase is a key regulator of circulating testosterone (T) and 17-β-oestradiol (E2), two steroids which are critical to the development, maintenance and function of reproductive tissues. The role of aromatase in sexual differentiation in oviparous (egg-laying) reptiles is well understood, yet has never been explored in viviparous (live-bearing) reptiles. As a first step towards understanding the functions of aromatase during gestation in viviparous reptiles, we measured aromatase activity in maternal and embryonic tissues at three stages of gestation in the viviparous skink, Niveoscincus metallicus. Maternal ovaries and adrenals maintained high aromatase activity throughout gestation. During the early phases of embryonic development, placental aromatase activity was comparable to that in maternal ovaries, but declined significantly at progressive stages of gestation. Aromatase activity in the developing brains and gonads of embryos was comparable with measurements in oviparous reptiles. Aromatase activity in the developing brains peaked mid development, and declined to low levels in late stage embryos. Aromatase activity in the embryonic gonads was low at embryonic stage 2934, but increased significantly at mid-development and then remained high in late stage embryos. We conclude that ovarian estrogen synthesis is supplemented by placental aromatase activity and that maternal adrenals provide an auxiliary source of sex steroid. The pattern of change in aromatase activity in embryonic brains and gonads suggests that brain aromatase is important during sexual differentiation, and that embryonic gonads are increasingly steroidogenic as development progresses. Our data indicate vital roles of aromatase in gestation and development in viviparous lizards.

Item Details

Item Type:Refereed Article
Keywords:aromatase, estradiol, placenta, reptile, testosterone, viviparity
Research Division:Biological Sciences
Research Group:Ecology
Research Field:Behavioural Ecology
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Environmental Sciences
Author:Parsley, LM (Dr Laura Parsley)
Author:Wapstra, E (Associate Professor Erik Wapstra)
Author:Jones, SM (Professor Susan Jones)
ID Code:90980
Year Published:2014
Funding Support:Australian Research Council (FT110100597)
Web of Science® Times Cited:2
Deposited By:Zoology
Deposited On:2014-05-05
Last Modified:2017-10-31
Downloads:0

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