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Nonechocardiographic imaging in evaluation for cardiac resynchronization therapy


AlJaroudi, W and Chen, J and Jaber, WA and Lloyd, SG and Cerqueira, MD and Marwick, TH, Nonechocardiographic imaging in evaluation for cardiac resynchronization therapy, Circulation: Cardiovascular Imaging, 4, (3) pp. 334-343. ISSN 1941-9651 (2011) [Refereed Article]

Copyright Statement

Copyright 2011 American Heart Association

DOI: doi:10.1161/circimaging.111.963504


In patients with heart failure and prolonged QRS duration, randomized clinical trials have shown that cardiac resynchronization therapy (CRT) is associated with improvement in quality of life, left ventricular (LV) remodeling, and survival.13 The improvements are believed to be mediated by more effective synchronized contraction in the presence of a wide QRS, but mechanical and electrical dyssynchrony are not equivalent.4,5 Although the concept of CRT response remains problematic,6 20% to 40% of patients who receive CRT based on electrical dyssynchrony criteria (ie, QRS duration) do not derive symptom improvement or demonstrate reverse remodeling.710 Scar burden1113 and failure to place the LV pacing lead at the site of latest onset of contraction1417 have been linked to a poor response. Thus, optimal clinical decision-making for CRT must include a comprehensive evaluation of all these factors to identify patients with heart failure who will benefit.

Item Details

Item Type:Refereed Article
Keywords:cardiac resynchronization therapy, ventricular function left, heart failure
Research Division:Biomedical and Clinical Sciences
Research Group:Cardiovascular medicine and haematology
Research Field:Cardiology (incl. cardiovascular diseases)
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Marwick, TH (Professor Tom Marwick)
ID Code:90932
Year Published:2011
Web of Science® Times Cited:20
Deposited By:Menzies Institute for Medical Research
Deposited On:2014-05-01
Last Modified:2014-06-06

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