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Cardiac and vascular structure and function parameters do not improve with alternate nightly home hemodialysis: an interventional cohort study

Citation

van Eps, CL and Jeffriess, L and Haluska, B and Hawley, CM and Coombes, J and Matsumoto, A and Jeffries, JK and Johnson, DW and Campbell, SB and Isbel, NM and Mudge, DW and Marwick, TH, Cardiac and vascular structure and function parameters do not improve with alternate nightly home hemodialysis: an interventional cohort study, BMC Nephrology, 12, (10) Article 51. ISSN 1471-2369 (2011) [Refereed Article]


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Licenced under Creative Commons Attribution 2.0 Generic (CC BY 2.0) http://creativecommons.org/licenses/by/2.0/

DOI: doi:10.1186/1471-2369-12-51

Abstract

Background Nightly extended hours hemodialysis may improve left ventricular hypertrophy and function and endothelial function but presents problems of sustainability and increased cost. The effect of alternate nightly home hemodialysis (NHD) on cardiovascular structure and function is not known.
Methods Sixty-three patients on standard hemodialysis (SHD: 3.5-6 hours/session, 3-5 sessions weekly) converted to NHD (6-10 hours/session overnight for 3-5 sessions weekly). 2Dimensional transthoracic echocardiography and ultrasound measures of brachial artery reactivity (BAR), carotid intima-media thickness (CIMT), total arterial compliance (TAC) and augmentation index (AIX) were performed post dialysis at baseline and 18-24 months following conversion to NHD. In 37 patients, indices of oxidative stress: plasma malonyldialdehyde (MDA) and anti-oxidant enzymes: catalase (CAT), glutathione peroxidase (GPX) and superoxide dismutase (SOD) activity and total antioxidant status (TAS) were measured at baseline, 3 and 6 months.
Results Left ventricular mass index (LVMI) remained stable. Despite significant derangement at baseline, there were no changes in diastolic function measures, CIMT, BAR and TAC. AIX increased. Conversion to NHD improved bone mineral metabolism parameters and blood pressure control. Interdialytic weight gains increased. No definite improvements in measures of oxidative stress were demonstrated.
Conclusions Despite improvement in uremic toxin levels and some cardiovascular risk factors, conversion to an alternate nightly NHD regimen did not improve cardiovascular structure and function. Continuing suboptimal control of uremic toxins and interdialytic weight gains may be a possible explanation. This study adds to the increasing uncertainty about the nature of improvement in cardiovascular parameters with conversion to intensive hemodialysis regimens. Future randomized controlled trials will be important to determine whether increases in dialysis session duration, frequency or both are most beneficial for improving cardiovascular disease whilst minimizing costs and the impact of dialysis on quality of life.

Item Details

Item Type:Refereed Article
Keywords:diastolic function, ejection fraction, left ventricular mass index, left ventricular hypertrophy, nocturnal hemodialysis, carotid intima-media thickness, oxidative stress, arterial compliance
Research Division:Medical and Health Sciences
Research Group:Cardiorespiratory Medicine and Haematology
Research Field:Cardiology (incl. Cardiovascular Diseases)
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Cardiovascular System and Diseases
Author:Marwick, TH (Professor Tom Marwick)
ID Code:90909
Year Published:2011
Web of Science® Times Cited:5
Deposited By:Menzies Institute for Medical Research
Deposited On:2014-05-01
Last Modified:2014-07-01
Downloads:431 View Download Statistics

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