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The cross-sectional association of sitting time with carotid artery stiffness in young adults

Citation

Huynh, QL and Blizzard, CL and Sharman, JE and Magnussen, CG and Dwyer, T and Venn, AJ, The cross-sectional association of sitting time with carotid artery stiffness in young adults, BMJ Open, 4, (3) Article e004384. ISSN 2044-6055 (2014) [Refereed Article]


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Copyright 2014 BMJ Licenced under Creative Commons Attribution-Non Commercial 3.0 Unported (CC BY-NC 3.0) http://creativecommons.org/licenses/by-nc/3.0/

DOI: doi:10.1136/bmjopen-2013-004384

Abstract

OBJECTIVES: Physical activity is negatively associated with arterial stiffness. However, the relationship between sedentary behaviour and arterial stiffness is poorly understood. In this study, we aimed to investigate the association of sedentary behaviour with arterial stiffness among young adults. DESIGN: Cross-sectional. SETTING: 34 study clinics across Australia during 2004-2006. PARTICIPANTS: 2328 participants (49.4% male) aged 26-36 years who were followed up from a nationally representative sample of Australian schoolchildren in 1985. MEASUREMENTS: Arterial stiffness was measured by carotid ultrasound. Sitting time per weekday and weekend day, and physical activity were self-reported by questionnaire. Cardiorespiratory fitness was estimated as physical work capacity at a heart rate of 170 bpm. Anthropometry, blood pressure, resting heart rate and blood biochemistry were measured. Potential confounders, including strength training, education, smoking, diet, alcohol consumption and parity, were self-reported. Rank correlation was used for analysis. RESULTS: Sitting time per weekend day, but not per weekday, was correlated with arterial stiffness (males r=0.11 p<0.01, females r=0.08, p<0.05) and cardiorespiratory fitness (males r = -0.14, females r = -0.08, p<0.05), and also with fatness and resting heart rate. One additional hour of sitting per weekend day was associated with 5.6% (males p=0.046) and 8.6% (females p=0.05) higher risk of having metabolic syndrome. These associations were independent of physical activity and other potential confounders. The association of sitting time per weekend day with arterial stiffness was not mediated by resting heart rate, fatness or metabolic syndrome. CONCLUSIONS: Our study demonstrates a positive association of sitting time with arterial stiffness. The greater role of sitting time per weekend day in prediction of arterial stiffness and cardiometabolic risk than that of sitting time per weekday may be due to better reflection of discretionary sitting behaviour.

Item Details

Item Type:Refereed Article
Keywords:Epidemiology, preventive medicine
Research Division:Medical and Health Sciences
Research Group:Public Health and Health Services
Research Field:Epidemiology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Cardiovascular System and Diseases
Author:Huynh, QL (Dr Quan Huynh)
Author:Blizzard, CL (Associate Professor Leigh Blizzard)
Author:Sharman, JE (Professor James Sharman)
Author:Magnussen, CG (Dr Costan Magnussen)
Author:Dwyer, T (Professor Terry Dwyer)
Author:Venn, AJ (Professor Alison Venn)
ID Code:90892
Year Published:2014
Web of Science® Times Cited:5
Deposited By:Menzies Institute for Medical Research
Deposited On:2014-04-30
Last Modified:2017-11-02
Downloads:253 View Download Statistics

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