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Genome-wide association studies in the hunt for genes causing primary open-angle glaucoma: a review

Citation

Burdon, KP, Genome-wide association studies in the hunt for genes causing primary open-angle glaucoma: a review, Clinical and Experimental Ophthalmology, 40, (4) pp. 358-363. ISSN 1442-6404 (2012) [Refereed Article]

Copyright Statement

Copyright 2012 the Authors Copyright 2012 Royal Australian and New Zealand College of Ophthalmologists

Official URL: http://www.ranzco.edu/images/documents/Intellectua...

DOI: doi:10.1111/j.1442-9071.2011.02744.x

Abstract

Genome-wide association studies are a powerful tool for the identification of genetic risk factors for complex disease. This methodology has been successfully applied to primary open-angle glaucoma through the analysis of primary open-angle glaucoma (POAG) as well as specific subgroups of patients including those with normal tension glaucoma and advanced glaucoma. In addition, the analysis of quantitative traits important in POAG, including optic disc area and vertical cup-to-disc ratio has also identified genes important in POAG development. This review explores findings of genome-wide association studies for POAG and related traits.

Item Details

Item Type:Refereed Article
Keywords:endophenotype, genetics, primary open-angle glaucoma, quantitative trait loci
Research Division:Medical and Health Sciences
Research Group:Ophthalmology and Optometry
Research Field:Ophthalmology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Hearing, Vision, Speech and Their Disorders
Author:Burdon, KP (Associate Professor Kathryn Burdon)
ID Code:90884
Year Published:2012
Web of Science® Times Cited:15
Deposited By:Menzies Institute for Medical Research
Deposited On:2014-04-30
Last Modified:2014-05-01
Downloads:0

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