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Genome-wide association studies in the hunt for genes causing primary open-angle glaucoma: a review
Genome-wide association studies are a powerful tool for the identification of genetic risk factors for complex disease. This methodology has been successfully applied to primary open-angle glaucoma through the analysis of primary open-angle glaucoma (POAG) as well as specific subgroups of patients including those with normal tension glaucoma and advanced glaucoma. In addition, the analysis of quantitative traits important in POAG, including optic disc area and vertical cup-to-disc ratio has also identified genes important in POAG development. This review explores findings of genome-wide association studies for POAG and related traits.
History
Publication title
Clinical and Experimental OphthalmologyVolume
40Issue
4Pagination
358-363ISSN
1442-6404Department/School
Menzies Institute for Medical ResearchPublisher
Blackwell Publishing AsiaPlace of publication
54 University St, P O Box 378, Carlton, Australia, Victoria, 3053Rights statement
Copyright 2012 the Authors Copyright 2012 Royal Australian and New Zealand College of OphthalmologistsRepository Status
- Restricted