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Effects of perhexiline on myocardial deformation in patients with ischaemic left ventricular dysfunction


Bansal, M and Chan, J and Leano, R and Pillans, P and Horowitz, J and Marwick, TH, Effects of perhexiline on myocardial deformation in patients with ischaemic left ventricular dysfunction, International Journal of Cardiology, 139, (2) pp. 107-112. ISSN 0167-5273 (2010) [Refereed Article]

Copyright Statement

Copyright 2010 Elsevier Ireland

DOI: doi:10.1016/j.ijcard.2009.08.007


Background Perhexiline improves functional capacity in heart failure, but the mechanisms are undefined. We sought its effects on myocardial deformation in patients with viable myocardium.
Methods Thirty-six medically-treated patients, stable at least 6 months post-infarction with LV dysfunction and myocardial viability shown by dobutamine echo (DbE) were randomised to receive perhexiline or matching placebo for 1 year. Cardiopulmonary exercise testing and DbE were performed at baseline and follow-up. Peak-systolic strain (S) and strain rate (SR) were measured offline in 111 dysfunctional segments in the placebo and 88 in the treatment group at rest, low-dose (LDD) and peak-dose dobutamine (PDD).
Results The serum perhexiline level was 0.27 0.7 g/l. There was no difference in the wall motion response to dobutamine at baseline and follow-up. Resting strain and SR were similar in the two groups at baseline and follow-up. However, SR at LDD and PDD increased in the placebo group and worsened during the same period in the perhexiline group. Patients on perhexiline and placebo had a similar rate-pressure product and exercise duration at baseline (7.9 2.7 vs 8.7 3.3 min, p = NS) and follow-up (9.6 4.6 vs 10.1 3.03 min, p = NS).
Conclusion Perhexiline does not improve the deformation of abnormal myocardial segments in patients with ischaemic LV dysfunction.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Cardiovascular medicine and haematology
Research Field:Cardiology (incl. cardiovascular diseases)
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Marwick, TH (Professor Tom Marwick)
ID Code:90878
Year Published:2010
Web of Science® Times Cited:7
Deposited By:Menzies Institute for Medical Research
Deposited On:2014-04-30
Last Modified:2014-05-01

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