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A comparison of methods for assessing total arterial compliance
Citation
Haluska, BA and Jeffriess, L and Brown, J and Carlier, S and Marwick, TH, A comparison of methods for assessing total arterial compliance, Journal of Human Hypertension, 24, (4) pp. 254-262. ISSN 0950-9240 (2010) [Refereed Article]
Copyright Statement
Copyright 2010 Macmillan Publishers
Abstract
There are several methods of assessing total arterial
compliance (TAC) based on the two element Windkessel
model, which is a ratio of pressure and volume, but the
optimal technique is unclear. In this study, three methods
of estimating TAC were compared to determine which
was the most robust in a large group of patients with and
without cardiovascular risk. In all, 320 patients (170 men;
age 55±10) were studied; TAC was determined by the
pulse-pressure method (PPM), the area method (AM)
and the stroke volume/pulse-pressure method (SVPP).
We obtained arterial waveforms using radial applanation
tonometry, dimensions using two-dimensional echocardiography
and flow data by Doppler. Clinical data, risk
factors, echo parameters and TAC by all three methods
were then compared. TAC (mlmmHg–1) by the PPM was
1.24±0.51, by the AM 1.84±0.90 and by the SVPP
1.96±0.76 (P<0.0001 between groups). Correlation was
good between all methods: PPM/AM r=0.83, PPM/SVPP
r=0.94 and AM/SVPP r=0.80 (all P<0.0001). Subgroup
analysis showed significant differences between patients
with and those without cardiovascular risk for all three
methods; TAC–AM and TAC–SVPP values were similar
and significantly higher than TAC–PPM. The only significant
relationships observed with TAC and echo
parameters were in left ventricular (LV) septal thickness
(R2=0.07; P<0.0001) and LV mass (R2=0.04; P=0.004).
Normal and abnormal values of TAC vary according to
method, which should be expressed. Each of the techniques
shows good correlation with each other, however,
values for TAC–PPM are significantly lower. TAC–PPM
and TAC–SVPP are comparable in determining differences
between groups with and without cardiovascular risk.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | total arterial compliance, pulse-pressure method, cardiovascular risk |
| Research Division: | Biomedical and Clinical Sciences |
| Research Group: | Cardiovascular medicine and haematology |
| Research Field: | Cardiology (incl. cardiovascular diseases) |
| Objective Division: | Health |
| Objective Group: | Clinical health |
| Objective Field: | Clinical health not elsewhere classified |
| UTAS Author: | Marwick, TH (Professor Tom Marwick) |
| ID Code: | 90872 |
| Year Published: | 2010 |
| Web of Science® Times Cited: | 14 |
| Deposited By: | Menzies Institute for Medical Research |
| Deposited On: | 2014-04-30 |
| Last Modified: | 2014-12-17 |
| Downloads: | 0 |
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