Haluska, BA and Jeffries, L and Carlier, S and Marwick, TH, Measurement of arterial distensibility and compliance to assess prognosis, Atherosclerosis, 209, (2) pp. 474-480. ISSN 0021-9150 (2010) [Refereed Article]
Copyright 2010 Elsevier
Methods Clinical data including blood pressure (BP) and diabetes mellitus (DM) were obtained and Framingham 10-year risk was calculated in 719 primary prevention patients (373 men; age 55 ± 11 years). TAC was calculated from applanation tonometry using the pulse-pressure method, 2D-echocardiography and Doppler, and DC was derived from 2D measurements of the common carotid artery and pulse pressure (PP). Cox regression analysis was performed to determine correlates of outcome.
Results There were 42 deaths (5.8%) and 114 cardiovascular admissions (15.8%) over 57 months. The independent correlates of mortality were Framingham 10-year risk (HR = 1.69; p < 0.0001) and DC (HR = 0.54; p = 0.02) (model chi-square 24.52; p < 0.0001) but not TAC. The independent predictors of the composite outcome of either death or admission for cardiovascular causes were Framingham 10-year risk (HR = 1.28; p = 0.001) and TAC (HR = 0.75; p = 0.006) (model chi-square 21.43; p < 0.0001) but not DC.
Conclusions Measurement of arterial function is independently correlated with outcome in patients with varying degrees of cardiovascular risk, and different aspects identify fatal and non-fatal events. In addition, measurement of TAC and DC adds incremental benefit to Framingham risk scores alone in patients with intermediate cardiovascular risk.
|Item Type:||Refereed Article|
|Keywords:||total arterial compliance, arterial distensibility, framingham risk; outcome|
|Research Division:||Medical and Health Sciences|
|Research Group:||Cardiorespiratory Medicine and Haematology|
|Research Field:||Cardiology (incl. Cardiovascular Diseases)|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Cardiovascular System and Diseases|
|Author:||Marwick, TH (Professor Tom Marwick)|
|Web of Science® Times Cited:||15|
|Deposited By:||Menzies Institute for Medical Research|
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