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Echocardiographic assessment of raised pulmonary vascular resistance: application to diagnosis and follow-up of pulmonary hypertension
journal contribution
posted on 2023-05-18, 00:05 authored by Dahiya, A, Vollbon, W, Jellis, C, Prior, D, Wahi, S, Thomas MarwickThomas MarwickObjective To optimise an echocardiographic estimation of pulmonary vascular resistance (PVRe) for diagnosis and follow-up of pulmonary hypertension (PHT).
Design Cross-sectional study.
Setting Tertiary referral centre.
Patients Patients undergoing right heart catheterisation and echocardiography for assessment of suspected PHT.
Methods PVRe ([tricuspid regurgitation velocity X10/ (right ventricular outflow tract velocity-time integral +0.16) and invasive PVRi ((mean pulmonary artery systolic pressure-wedge pressure)/cardiac output) were compared in 72 patients. Other echo data included right ventricular systolic pressure (RVSP), estimated right atrial pressure, and E/e' ratio. Difference between PVRe and PVRi at various levels of PVR was sought using Blande-Altman analysis. Corrected PVRc ((RVSP-E/e')/ RVOTVTI) (RVOT, RV outflow time; VTI, velocity time integral) was developed in the training group and tested in a separate validation group of 42 patients with established PHT.
Results PVRe>2.0 had high sensitivity (93%) and specificity (91%) for recognition of PVRi>2.0, and PVRc provided similar sensitivities and specificities. PVRe and PVRi correlated well (r=0.77, p<0.01), but PVRe underestimated marked elevation of PVRi-a trend avoided by PVRc. PVRc and PVRe were tested against PVRi in a separate validation group (n=42). The mean difference between PVRe and PVRi exceeded that between PVRc and PVRi (2.8+-2.7 vs 0.8+-3.0 Wood units; p<0.001). A drop in PVRi by at least one SD occurred in 10 patients over 6 months; this was detected in one patient by PVRe and eight patients by PVRc (p=0.002).
Conclusion PVRe distinguishes normal from abnormal PVRi but underestimates high PVRi. PVRc identifies the severity of PHT and may be used to assess treatment response.
Design Cross-sectional study.
Setting Tertiary referral centre.
Patients Patients undergoing right heart catheterisation and echocardiography for assessment of suspected PHT.
Methods PVRe ([tricuspid regurgitation velocity X10/ (right ventricular outflow tract velocity-time integral +0.16) and invasive PVRi ((mean pulmonary artery systolic pressure-wedge pressure)/cardiac output) were compared in 72 patients. Other echo data included right ventricular systolic pressure (RVSP), estimated right atrial pressure, and E/e' ratio. Difference between PVRe and PVRi at various levels of PVR was sought using Blande-Altman analysis. Corrected PVRc ((RVSP-E/e')/ RVOTVTI) (RVOT, RV outflow time; VTI, velocity time integral) was developed in the training group and tested in a separate validation group of 42 patients with established PHT.
Results PVRe>2.0 had high sensitivity (93%) and specificity (91%) for recognition of PVRi>2.0, and PVRc provided similar sensitivities and specificities. PVRe and PVRi correlated well (r=0.77, p<0.01), but PVRe underestimated marked elevation of PVRi-a trend avoided by PVRc. PVRc and PVRe were tested against PVRi in a separate validation group (n=42). The mean difference between PVRe and PVRi exceeded that between PVRc and PVRi (2.8+-2.7 vs 0.8+-3.0 Wood units; p<0.001). A drop in PVRi by at least one SD occurred in 10 patients over 6 months; this was detected in one patient by PVRe and eight patients by PVRc (p=0.002).
Conclusion PVRe distinguishes normal from abnormal PVRi but underestimates high PVRi. PVRc identifies the severity of PHT and may be used to assess treatment response.
History
Publication title
HeartVolume
96Issue
24Pagination
2005-2009ISSN
1355-6037Department/School
Menzies Institute for Medical ResearchPublisher
B M J Publishing GroupPlace of publication
British Med Assoc House, Tavistock Square, London, England, Wc1H 9JrRights statement
Copyright 2010 BMJ Publishing Group Ltd and the British Cardiovascular SocietyRepository Status
- Restricted