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Echocardiographic assessment of raised pulmonary vascular resistance: application to diagnosis and follow-up of pulmonary hypertension


Dahiya, A and Vollbon, W and Jellis, C and Prior, D and Wahi, S and Marwick, TH, Echocardiographic assessment of raised pulmonary vascular resistance: application to diagnosis and follow-up of pulmonary hypertension, Heart, 96, (24) pp. 2005-2009. ISSN 1355-6037 (2010) [Refereed Article]

Copyright Statement

Copyright 2010 BMJ Publishing Group Ltd and the British Cardiovascular Society

DOI: doi:10.1136/hrt.2010.204834


Objective To optimise an echocardiographic estimation of pulmonary vascular resistance (PVRe) for diagnosis and follow-up of pulmonary hypertension (PHT).
Design Cross-sectional study.
Setting Tertiary referral centre.
Patients Patients undergoing right heart catheterisation and echocardiography for assessment of suspected PHT.
Methods PVRe ([tricuspid regurgitation velocity X10/ (right ventricular outflow tract velocity-time integral +0.16) and invasive PVRi ((mean pulmonary artery systolic pressure-wedge pressure)/cardiac output) were compared in 72 patients. Other echo data included right ventricular systolic pressure (RVSP), estimated right atrial pressure, and E/e ratio. Difference between PVRe and PVRi at various levels of PVR was sought using Blande-Altman analysis. Corrected PVRc ((RVSP-E/e)/ RVOTVTI) (RVOT, RV outflow time; VTI, velocity time integral) was developed in the training group and tested in a separate validation group of 42 patients with established PHT.
Results PVRe>2.0 had high sensitivity (93%) and specificity (91%) for recognition of PVRi>2.0, and PVRc provided similar sensitivities and specificities. PVRe and PVRi correlated well (r=0.77, p<0.01), but PVRe underestimated marked elevation of PVRi-a trend avoided by PVRc. PVRc and PVRe were tested against PVRi in a separate validation group (n=42). The mean difference between PVRe and PVRi exceeded that between PVRc and PVRi (2.82.7 vs 0.83.0 Wood units; p<0.001). A drop in PVRi by at least one SD occurred in 10 patients over 6 months; this was detected in one patient by PVRe and eight patients by PVRc (p=0.002).
Conclusion PVRe distinguishes normal from abnormal PVRi but underestimates high PVRi. PVRc identifies the severity of PHT and may be used to assess treatment response.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Cardiovascular medicine and haematology
Research Field:Cardiology (incl. cardiovascular diseases)
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Marwick, TH (Professor Tom Marwick)
ID Code:90862
Year Published:2010
Web of Science® Times Cited:30
Deposited By:Menzies Institute for Medical Research
Deposited On:2014-04-29
Last Modified:2014-12-17

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