Jenkins, C and Moir, S and Chan, J and Rakhit, D and Haluska, B and Marwick, TH, Left ventricular volume measurement with echocardiography: a comparison of left ventricular opacification, three-dimensional echocardiography, or both with magnetic resonance imaging, European Heart Journal, 30, (1) pp. 98-106. ISSN 0195-668X (2009) [Refereed Article]
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Methods and results We studied 50 patients (46 men, age 63±10 year) with past myocardial infarction who underwent echocardiographic assessment of LV volume and function. All patients sequentially underwent NC-2DE followed by NC-3DE. CE-2DE and CE-3DE were acquired during contrast infusion. Resting echocardiographic image quality was evaluated on the basis of NC-2DE. The mean LV end-diastolic volume (LVEDV) of the group by MRI was 207±79 mL and was underestimated by 2DE (125±54 mL, P = 0.005), and less by CE-2DE (172±58 mL, P = 0.02) or 3DE (177±64 mL, P = 0.08), but EDV was comparable by CE-3DE (196±69 mL, P = 0.16). Limits of agreement with MRI were similar for NC-3DE and CE-2DE, with the best results for CE-3D. Results were similar for calculation of LVESV. Patients were categorized into groups of EF (≤35, 35–50, .50%) by MRI. NC-2DE demonstrated a 68% agreement (kappa 0.45, P = 0.001), CE-2DE a 62% agreement (kappa 0.20, P = 136), NC-3DE a 74% agreement (kappa 0.39, P = 0.005) and CE-3DE an 80% agreement (kappa 0.56, P < 0.001).
Conclusion CE-2DE is analogous to NC-3DE in accurate categorization of LV function. However, CE-3DE is feasible and superior to other NC- and CE-techniques in patients with previous infarction.
|Item Type:||Refereed Article|
|Keywords:||contrast-enhancement, left ventricular volumes, two-dimensional echocardiography, three-dimensional echocardiography|
|Research Division:||Medical and Health Sciences|
|Research Group:||Cardiorespiratory Medicine and Haematology|
|Research Field:||Cardiology (incl. Cardiovascular Diseases)|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Cardiovascular System and Diseases|
|Author:||Marwick, TH (Professor Tom Marwick)|
|Web of Science® Times Cited:||103|
|Deposited By:||Menzies Institute for Medical Research|
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