Eshoo, S and Boyd, AC and Ross, DL and Marwick, TH and Thomas, L, Strain rate evaluation of phasic atrial function in hypertension, Heart, 95, (14) pp. 1184-1191. ISSN 1355-6037 (2009) [Refereed Article]
Copyright 2009 BMJ
Objective: To examine the feasibility of using SI and SR to evaluate phasic atrial function in patients with mild hypertension (HT).
Patients and methods: The study group comprised 54 patients with mild essential HT (29 women) and 80 age-matched normal controls (47 women). Standard two-dimensional and Doppler echocardiography was performed as well as Doppler tissue imaging. The following left atrial (LA) volumes were measured: (a) maximal LA volume or Volmax; (b) minimal LA volume or Volmin; (c) just before the ‘‘p’’ wave on ECG (Volp). Phasic LA volumes were also calculated. Systolic (S-Sr), early diastolic (E-Sr), late diastolic (A-Sr) strain rate and SI were measured.
Results: Despite no differences in indexed maximal LA volume with only mild increases in left ventricular mass in the HT cohort compared with normal subjects (mean (SD) 86 (18) g/m2 vs 67 (14) g/m2; p=0.001), E-Sr was significantly lower in the HT cohort. There was a corresponding reduction in indexed conduit volume in the HT cohort compared with normal subjects (10.5 (7.5) ml/m2 vs 13.8 (6.1) ml/m2; p=0.006). Global E-Sr showed modest negative correlations with LA Volmax and LA ejection fraction. No significant difference was present in S-Sr, A-Sr or global atrial strain between the normal and HT cohorts.
Conclusion: Mild HT results in a reduction in LA conduit volume, although maximal LA volume is unchanged. This is reflected by a reduction in E-Sr with preserved S-Sr andA-Sr.
|Item Type:||Refereed Article|
|Research Division:||Medical and Health Sciences|
|Research Group:||Cardiorespiratory Medicine and Haematology|
|Research Field:||Cardiology (incl. Cardiovascular Diseases)|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Cardiovascular System and Diseases|
|Author:||Marwick, TH (Professor Tom Marwick)|
|Web of Science® Times Cited:||35|
|Deposited By:||Menzies Institute for Medical Research|
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