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Interaction of left ventricular geometry and myocardial ischemia in the response of myocardial deformation to stress
Citation
Stanton, T and Ingul, CB and Hare, JL and Leano, R and Marwick, TH, Interaction of left ventricular geometry and myocardial ischemia in the response of myocardial deformation to stress, The American Journal of Cardiology, 104, (7) pp. 897-903. ISSN 0002-9149 (2009) [Refereed Article]
Copyright Statement
Copyright 2009 Elsevier Inc. All rights reserved.
DOI: doi:10.1016/j.amjcard.2009.05.028
Abstract
Myocardial deformation parameters are sensitive markers of global left ventricular (LV)
systolic function, but their interaction with LV geometry is unknown. We sought to investigate
the effect of LV geometry on myocardial deformation and its interaction with coronary artery
disease (CAD). A total of 126 patients with normal resting LV function who underwent
dobutamine stress echocardiography subsequently underwent coronary angiography within 6
months. Longitudinal myocardial deformation was calculated using tissue Doppler echocardiography.
The extent of CAD was identified by quantitative coronary angiography. Patients
with an increased relative wall thickness had a significantly lower peak strain rate (SR) and a
smaller change in SR with stress, with no differences in the at rest values. Those with CAD, had
significantly lower peak SR values and change in SR with no difference in resting measures. A
linear regression model showed that the relative wall thickness and extent of CAD were the
strongest predictors of change in SR. An increasing extent of CAD caused a steady degradation
in the peak SR and change in peak SR. Markers of longitudinal myocardial deformation at
peak stress reflect both myocardial and interstitial properties. In conclusion, a major determinant
of subendocardial function is the wall thickness, as measured by the relative wall thickness,
and not LV hypertrophy.
Item Details
Item Type: | Refereed Article |
---|---|
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Cardiovascular medicine and haematology |
Research Field: | Cardiology (incl. cardiovascular diseases) |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | Marwick, TH (Professor Tom Marwick) |
ID Code: | 90760 |
Year Published: | 2009 |
Web of Science® Times Cited: | 3 |
Deposited By: | Menzies Institute for Medical Research |
Deposited On: | 2014-04-23 |
Last Modified: | 2014-12-17 |
Downloads: | 0 |
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